Weisz G, Udvardy M, Dalmi L, Kulcsár A
Acta Med Hung. 1983;40(2-3):155-64.
The serum alpha-fetoprotein level was measured by radioimmunoassay in 20 normal subjects and in 118 patients with chronic liver disease. The highest concentrations were found in the group of hepatocellular carcinoma. Compared with the controls, higher values were demonstrable in the other groups of liver disease as well. This is attributed to the more or less marked regeneration of liver tissue, which is never absent in any type of liver disease studied, and in the case of fatty degeneration, to the alpha-fetoprotein inducing effect of alcohol. The importance of alpha-fetoprotein estimation in the diagnosis of hepatocellular carcinoma and monitoring of its therapy, as also in the assessment of activity and regeneration in other forms of chronic liver disease, are pointed out. Countercurrent electrophoresis has been found unreliable for the measurement of alpha-fetoprotein.
采用放射免疫分析法对20名正常受试者和118例慢性肝病患者测定血清甲胎蛋白水平。肝细胞癌组中发现的浓度最高。与对照组相比，其他肝病组也显示出较高的值。这归因于或多或少明显的肝组织再生，在所研究的任何类型的肝病中这种再生都不会缺失，而在脂肪变性的情况下，则归因于酒精对甲胎蛋白的诱导作用。指出了甲胎蛋白测定在肝细胞癌诊断和治疗监测中的重要性，以及在评估其他形式慢性肝病的活动和再生方面的重要性。已发现对流电泳法测定甲胎蛋白不可靠。
