Lorizio A, Franciosi A
Riv Patol Nerv Ment. 1982 Sep-Oct;103(5):201-14.
The Authors describe a case of aphasia acquired in childhood together with epilepsy (syndrome of Landau and Kleffner) and treated for seven years. The patient had simple and complex partial attacks, motor dysphasia, frequent and heavy headache, and electroencephalographic paroxysmal anomalies with multifocal distribution. While the disease evolved with regression of disphasia and epilepsy, the EEG alterations persisted. In view of similar cases reported in the literature and the present treatment the Authors feel that syndrome is an inflammatory disease, its evolution being slow. The results of neuroradiological investigations support such hypothesis. The prognosis is poor (anomalies of speech persisted in 2 out of 3) and further studies are essential. A systematic use of cerebral biopsy is suggested.
作者描述了一例儿童期获得性失语症合并癫痫（Landau和Kleffner综合征）并接受了七年治疗的病例。患者有简单和复杂部分性发作、运动性失语、频繁且严重的头痛，以及脑电图阵发性异常且呈多灶性分布。随着疾病发展，失语症和癫痫症状有所缓解，但脑电图改变持续存在。鉴于文献中报道的类似病例及当前的治疗情况，作者认为该综合征是一种炎症性疾病，其进展缓慢。神经放射学检查结果支持这一假说。预后较差（三分之二的患者言语异常持续存在），进一步的研究至关重要。建议系统地进行脑活检。
