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一种新的多态性决定簇,与HLA - Bw44特异性不同但同时表达。

A new polymorphic determinant distinct from but expressed concomitantly with an HLA-Bw44 specificity.

作者信息

Sparrow R L, McKenzie I F

出版信息

Tissue Antigens. 1984 Jan;23(1):50-7. doi: 10.1111/j.1399-0039.1984.tb00008.x.

DOI:10.1111/j.1399-0039.1984.tb00008.x
PMID:6199868
Abstract

A new antigenic determinant defined by a monoclonal antibody (6.7) is described which displays restricted expression being present only on the cells of the immunizing donor and his father and not on a panel of over one hundred unrelated HLA-typed cells. The determinant segregated with the HLA haplotypes of the immunizing donor's family and was shown by immunochemical and capping studies to be located on a subpopulation of HLA molecules. Further capping and antibody-blocking studies using HLA-typing alloantisera revealed that the 6.7-reactive determinant was located on the same molecules that expressed the HLA-Bw44 specificity but was a separate epitope to the polymorphic HLA specificity.

摘要

描述了一种由单克隆抗体(6.7)定义的新抗原决定簇,其表达受限,仅存在于免疫供体及其父亲的细胞上,而不存在于一百多个无关的HLA分型细胞中。该决定簇与免疫供体家族的HLA单倍型分离,免疫化学和封帽研究表明其位于HLA分子的一个亚群上。使用HLA分型同种异体抗血清进行的进一步封帽和抗体阻断研究表明,6.7反应性决定簇位于表达HLA-Bw44特异性的相同分子上,但与多态性HLA特异性是一个单独的表位。

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