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In vivo and in vitro binding of alpha- and gamma-hexachlorocyclohexane to mouse liver macromolecules.

作者信息

Iverson F, Ryan J J, Lizotte R, Hierlihy S L

出版信息

Toxicol Lett. 1984 Mar;20(3):331-5. doi: 10.1016/0378-4274(84)90168-1.

DOI:10.1016/0378-4274(84)90168-1
PMID:6199873
Abstract

alpha-Hexachlorocyclohexane (alpha-HCH) but not gamma-HCH, produces a strong neoplastic response in HPB strain mouse liver. In vivo and in vitro binding studies with 14C-labelled HCH isomers showed no preferential binding of the alpha-HCH isomer to protein or DNA. Moreover, the binding of both isomers to DNA in vivo or in vitro occurred only at very low levels, a result consistent with the lack of mutagenic activity associated with these compounds. The results suggest that the neoplastic response observed with alpha-HCH results from a non-genotoxic mechanism.

摘要

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