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α-六氯环己烷的生物降解。VI. 大鼠肝脏微粒体和胞质溶胶对α-六氯环己烷的脱氯作用

Biodegradation of alpha-hexachlorocyclohexane. VI. The cechlorination of alpha-hexachlorocyclohexane by microsomes and cytosol of rat liver.

作者信息

Kraus P

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1975;291(1):79-87. doi: 10.1007/BF00510822.

DOI:10.1007/BF00510822
PMID:53794
Abstract

Alpha-hexachlorocyclohexane (alpha-HCH) is dechlorinated by enzymes contained in rat liver cytosol and microsomes. An evidence was obtained that in the cytosol there are two alpha-HCH dechlorinating enzymes at least; one operates only in the presence of reduced glutathione (GSH) and catalyzes dechlorinations associated with the formation of another hydrophilic product. This product is probably a conjugate of the alpha-HCH-residue with GSH. The other cytoplasmic alpha-HCH-dechlorinase requires no additions. The microsomes, too, contain two alpha-HC dechlorinases at least: one is stimulated by GSH, the other by NADPH.

摘要

α-六氯环己烷（α-HCH）可被大鼠肝细胞溶质和微粒体中的酶脱氯。有证据表明，在细胞溶质中至少存在两种α-HCH脱氯酶；一种仅在还原型谷胱甘肽（GSH）存在时起作用，并催化与另一种亲水性产物形成相关的脱氯反应。该产物可能是α-HCH残基与GSH的缀合物。另一种细胞质α-HCH脱氯酶则无需添加其他物质。微粒体中也至少含有两种α-HC脱氯酶：一种受GSH刺激，另一种受NADPH刺激。

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引用本文的文献

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Biodegradation of alpha-hexachlorocyclohexane. VII. Resolution, purification, and characterization of an alpha-HCH dechlorinating enzyme from rat liver cytosol.α-六氯环己烷的生物降解。VII. 大鼠肝细胞溶质中α-六氯环己烷脱氯酶的拆分、纯化及特性鉴定
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MEASUREMENT OF LOW ENERGY BETA-EMITTERS IN AQUEOUS SOLUTION BY LIQUID SCINTILLATION COUNTING OF EMULSIONS.通过乳液的液体闪烁计数法测量水溶液中的低能β发射体。
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