LeVeen H H, Rajagopalan P R, Vujic I, Gobien R P, O'Brien P H, Hutto R, Pontiggia P, D'Ovidio N, Pethig R, Armitage D
Am Surg. 1984 Feb;50(2):61-5.
Localized radiofrequency thermotherapy (RFTT) has been effective by itself in debulking cancers but has not accomplished total eradication by itself. Occlusion of the regional artery supplying the tumor drastically reduces the arterial pressure distal to occlusion and further impairs tumor blood flow leading to an accentuation of the temperature differentiation achieved by the normal tissue and tumor. Radiofrequency thermotherapy with vascular occlusion is combined with direct injection of an effective chemotherapeutic agent into the tumor. Radiofrequency thermotherapy is performed after injection of chemotherapy using bleomycin and mitomycin C for squamous cell cancers and Adriamycin and mitomycin C for adenocarcinoma. There are no adverse systemic responses to the small dose of chemotherapy used and the combination therapy is effective in destroying the tumor.
局部射频热疗（RFTT）本身在使癌症体积缩小方面是有效的，但无法单独实现完全根除。阻断供应肿瘤的局部动脉会大幅降低阻断远端的动脉压力，并进一步损害肿瘤血流，导致正常组织与肿瘤之间实现的温度差异加剧。血管闭塞联合射频热疗与向肿瘤内直接注射有效的化疗药物相结合。对于鳞状细胞癌，在注射使用博来霉素和丝裂霉素C的化疗药物后进行射频热疗；对于腺癌，则使用阿霉素和丝裂霉素C。所用小剂量化疗药物无不良全身反应，联合治疗在破坏肿瘤方面有效。
