Nunez E A, Benassayag C, Vallette G, Savu L, Clerc-Hofmann F, Delorme J, Christeff N
Ann N Y Acad Sci. 1983;417:137-48. doi: 10.1111/j.1749-6632.1983.tb32858.x.
We discuss the various experimental findings to date that indicate that AFP may be considered as a positive or negative modulator of estrogenic action. Moreover, we show that this protein, even when nonestrogenophilic, is able to bind other hydrophobic ligands, in particular nonesterified fatty acids. These fatty acids inhibit the binding of estrogens to murine AFP as well as to the cytosolic estrogen receptors. Thus, the AFPs of all species--whether or not estrogenophilic--might play an endocrinologic role through the intermediary of the unsaturated fatty acids to which they associate with high affinity.
我们讨论了迄今为止的各种实验结果，这些结果表明甲胎蛋白（AFP）可被视为雌激素作用的正性或负性调节剂。此外，我们表明这种蛋白质即使不具有亲雌激素性，也能够结合其他疏水性配体，特别是非酯化脂肪酸。这些脂肪酸抑制雌激素与小鼠AFP以及细胞溶质雌激素受体的结合。因此，所有物种的AFP——无论是否具有亲雌激素性——可能通过它们以高亲和力结合的不饱和脂肪酸作为媒介发挥内分泌作用。
