Bruggeman C A, Schellekens H, Grauls G, Debie W M, van Boven C P
Antiviral Res. 1983 Dec;3(5-6):315-24. doi: 10.1016/0166-3542(83)90039-6.
Rat interferon (IFN) in a dose-dependent fashion inhibited the cytopathic effect of rat cytomegalovirus (RCMV) in rat cell cultures. Treatment of Lewis and Brown Norway (BN) rats with intraperitoneal injections of IFN reduced the amount of virus recovered from the spleens at 3 days post infection (p.i.) and from the salivary glands at 10 and 21 days p.i. In cell cultures, RCMV failed to induce detectable amounts of IFN. Small amounts of IFN were detectable in the serum of BN rats at 3 days p.i. In Lewis rats no IFN was found in serum at any time during the first month p.i.
大鼠干扰素（IFN）以剂量依赖方式抑制大鼠巨细胞病毒（RCMV）在大鼠细胞培养物中的细胞病变效应。对Lewis大鼠和棕色挪威（BN）大鼠进行腹腔注射IFN治疗，可减少感染后3天从脾脏以及感染后10天和21天从唾液腺中回收的病毒量。在细胞培养中，RCMV未能诱导出可检测量的IFN。在感染后3天，可在BN大鼠血清中检测到少量IFN。在感染后的第一个月内，Lewis大鼠血清中在任何时候均未发现IFN。
