经人癌基因转化的干扰素处理小鼠细胞中表型逆转的生化关联
Biochemical correlates of phenotypic reversion in interferon-treated mouse cells transformed by a human oncogene.
作者信息
Samid D, Chang E H, Friedman R M
出版信息
Biochem Biophys Res Commun. 1984 Feb 29;119(1):21-8. doi: 10.1016/0006-291x(84)91612-7.
Mouse interferon (IFN) induced a phenotypic reversion in RS 485, a clonal line of NIH 3T3 oncogenically transformed by a human c-Ha-rasl gene activated by Ha-MuSV long terminal repeats (LTRs). Transfected c-Ha-ras DNA, unchanged in quantity and distribution, as compared to the parental RS 485 transformed cells, was still present in these revertants; however, there was a significant reduction in the amount of c-Ha-ras specific mRNA and of c-Ha-ras specified p21 protein.
小鼠干扰素（IFN）可诱导RS 485细胞发生表型逆转，RS 485是由Ha-MuSV长末端重复序列（LTR）激活的人c-Ha-ras1基因致癌转化的NIH 3T3克隆细胞系。与亲代RS 485转化细胞相比，转染的c-Ha-ras DNA在数量和分布上没有变化，在这些逆转细胞中仍然存在；然而，c-Ha-ras特异性mRNA和c-Ha-ras编码的p21蛋白的量显著减少。
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