干扰素对病毒基因和细胞基因所致遗传转化及致癌转化的抑制作用。
Inhibitory effect of interferon on the genetic and oncogenic transformation by viral and cellular genes.
作者信息
Perucho M, Esteban M
出版信息
J Virol. 1985 Apr;54(1):229-32. doi: 10.1128/JVI.54.1.229-232.1985.
Abstract
The rodent established cell lines LTk- and NIH 3T3 have been used as recipients in gene transfer experiments to study the effect of interferon treatment on the genetic and oncogenic transformation by several genes of viral and cellular origin. Our results show that interferon severely inhibits, to a similar extent, the stable transformation of Ltk- and NIH 3T3 cells by the chicken thymidine kinase (tk) gene, Ecogpt gene, simian virus 40, v-Ha-ras, and human c-Ha-ras and c-Ki-ras oncogenes. These results are consistent with an inhibition by interferon at the level of stabilization or integration, or both, of exogenous DNA sequences in the recipient cells, with an apparent effect on gene expression.
摘要
啮齿动物建立的细胞系LTk-和NIH 3T3已被用作基因转移实验的受体，以研究干扰素处理对几种病毒和细胞来源基因的遗传和致癌转化的影响。我们的结果表明，干扰素在相似程度上严重抑制鸡胸苷激酶（tk）基因、Ecogpt基因、猿猴病毒40、v-Ha-ras、人c-Ha-ras和c-Ki-ras癌基因对Ltk-和NIH 3T3细胞的稳定转化。这些结果与干扰素在受体细胞中外源DNA序列的稳定或整合水平或两者水平上的抑制作用一致，对基因表达有明显影响。
相似文献
1
Inhibitory effect of interferon on the genetic and oncogenic transformation by viral and cellular genes.干扰素对病毒基因和细胞基因所致遗传转化及致癌转化的抑制作用。
J Virol. 1985 Apr;54(1):229-32. doi: 10.1128/JVI.54.1.229-232.1985.
2
Development of transformed phenotype induced by a human ras oncogene is inhibited by interferon.人源ras癌基因诱导的转化表型的发展受到干扰素的抑制。
Biochem Biophys Res Commun. 1985 Jan 16;126(1):509-16. doi: 10.1016/0006-291x(85)90635-7.
3
Hamster cell line suitable for transfection assay of transforming genes.适用于转化基因转染分析的仓鼠细胞系。
Proc Natl Acad Sci U S A. 1990 Apr;87(7):2409-13. doi: 10.1073/pnas.87.7.2409.
4
Interferon inhibits transformation of mouse cells by exogenous cellular or viral genes.
Nature. 1983;303(5916):433-5. doi: 10.1038/303433a0.
5
Alterations in transformation efficiency by the ADPRT-inhibitor 3-aminobenzamide are oncogene specific.
Carcinogenesis. 1989 Feb;10(2):383-5. doi: 10.1093/carcin/10.2.383.
6
Glucocorticoid-dependent oncogenic transformation by type 16 but not type 11 human papilloma virus DNA.16型而非11型人乳头瘤病毒DNA介导的糖皮质激素依赖性致癌转化
Nature. 1988 Oct 27;335(6193):832-5. doi: 10.1038/335832a0.
7
Enhancement of viral and DNA mediated transformation of cloned rat embryo fibroblast cells by 3-aminobenzamide.3-氨基苯甲酰胺对克隆大鼠胚胎成纤维细胞的病毒介导和DNA介导转化的增强作用。
Mol Carcinog. 1990;3(5):309-18. doi: 10.1002/mc.2940030512.
8
9
Interferon-induced revertants of ras-transformed cells: resistance to transformation by specific oncogenes and retransformation by 5-azacytidine.干扰素诱导的ras转化细胞回复突变体：对特定癌基因转化的抗性及5-氮杂胞苷的再转化作用
Mol Cell Biol. 1987 Jun;7(6):2196-200. doi: 10.1128/mcb.7.6.2196-2200.1987.
10
Malignant transformation of a preneoplastic hamster epidermal cell line by the EJ c-Ha-ras-oncogene.EJ c-Ha-ras癌基因对癌前仓鼠表皮细胞系的恶性转化
Cancer Res. 1986 Mar;46(3):1458-64.
引用本文的文献
1
Genetic Programs Driving Oncogenic Transformation: Lessons from in Vitro Models.遗传程序驱动致癌转化：来自体外模型的教训。
Int J Mol Sci. 2019 Dec 12;20(24):6283. doi: 10.3390/ijms20246283.
2
GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses.GRIM-19：一把调控抗肿瘤和固有免疫反应的双刃剑。
Transl Oncogenomics. 2008 Mar 17;3:67-79.
3
Cytokine-induced tumor suppressors: a GRIM story.细胞因子诱导的肿瘤抑制因子：GRIM 的故事。
Cytokine. 2010 Oct-Nov;52(1-2):128-42. doi: 10.1016/j.cyto.2010.03.009. Epub 2010 Apr 10.
4
Tumor suppressive protein gene associated with retinoid-interferon-induced mortality (GRIM)-19 inhibits src-induced oncogenic transformation at multiple levels.与类视黄醇-干扰素诱导的细胞死亡相关的肿瘤抑制蛋白基因（GRIM）-19在多个水平上抑制src诱导的致癌转化。
Am J Pathol. 2007 Oct;171(4):1352-68. doi: 10.2353/ajpath.2007.070241. Epub 2007 Sep 6.
5
Interferon prevents the generation of spontaneous deletions at the left terminus of vaccinia virus DNA.干扰素可防止痘苗病毒DNA左端自发缺失的产生。
J Virol. 1985 Oct;56(1):75-84. doi: 10.1128/JVI.56.1.75-84.1985.
6
Virus attenuation and identification of structural proteins of vaccinia virus that are selectively modified during virus persistence.痘苗病毒的减毒以及对病毒持续存在期间被选择性修饰的结构蛋白的鉴定。
J Virol. 1987 Aug;61(8):2642-7. doi: 10.1128/JVI.61.8.2642-2647.1987.
7
Murine gamma interferon inhibits v-mos-induced fibroblast transformation via down regulation of retroviral gene expression.小鼠γ干扰素通过下调逆转录病毒基因表达来抑制v-mos诱导的成纤维细胞转化。
J Virol. 1987 Aug;61(8):2567-72. doi: 10.1128/JVI.61.8.2567-2572.1987.
8
Depression of early phase of HTLV-I infection in vitro mediated by human beta-interferon.人β-干扰素介导的HTLV-I感染早期阶段的体外抑制
Br J Cancer. 1988 May;57(5):481-8. doi: 10.1038/bjc.1988.111.
9
Regulated expression of nuclear genes by T3 RNA polymerase and lac repressor, using recombinant vaccinia virus vectors.使用重组痘苗病毒载体通过T3 RNA聚合酶和乳糖阻遏物对核基因进行调控表达。
J Virol. 1990 Oct;64(10):4851-7. doi: 10.1128/JVI.64.10.4851-4857.1990.
本文引用的文献
1
Normal rat cell lines deficient in nuclear thymidine kinase.缺乏细胞核胸苷激酶的正常大鼠细胞系。
Virology. 1981 Aug;113(1):408-11. doi: 10.1016/0042-6822(81)90168-9.
2
Transforming DNA integrates into the host chromosome.转化DNA整合到宿主染色体中。
Cell. 1981 Jan;23(1):29-39. doi: 10.1016/0092-8674(81)90267-1.
3
Oncogenes in solid human tumours.人类实体瘤中的癌基因。
Nature. 1982 Dec 9;300(5892):539-42. doi: 10.1038/300539a0.
4
Analysis of replicating vaccinia DNA in interferon-treated, virus-infected cells.在干扰素处理的、病毒感染细胞中对复制的痘苗病毒DNA的分析。
J Interferon Res. 1984 Spring;4(2):179-92. doi: 10.1089/jir.1984.4.179.
5
Inhibition of cell proliferation by interferons. 2. Changes in processing and stability of newly synthesized DNA in human lymphoblastoid (Daudi) cells.
Eur J Biochem. 1984 Mar 15;139(3):627-35. doi: 10.1111/j.1432-1033.1984.tb08050.x.
6
Selective reduction of c-myc mRNA in Daudi cells by human beta interferon.人β干扰素对Daudi细胞中c-myc信使核糖核酸的选择性降低作用
Proc Natl Acad Sci U S A. 1984 Mar;81(6):1747-50. doi: 10.1073/pnas.81.6.1747.
7
Three human transforming genes are related to the viral ras oncogenes.三种人类转化基因与病毒ras癌基因相关。
Proc Natl Acad Sci U S A. 1983 Apr;80(8):2112-6. doi: 10.1073/pnas.80.8.2112.
8
Cellular oncogenes and multistep carcinogenesis.细胞癌基因与多步骤致癌作用
Science. 1983 Nov 18;222(4625):771-8. doi: 10.1126/science.6356358.
9
Resistance of vaccinia virus to interferon is related to an interference phenomenon between the virus and the interferon system.痘苗病毒对干扰素的抗性与病毒和干扰素系统之间的干扰现象有关。
Virology. 1984 Apr 15;134(1):12-28. doi: 10.1016/0042-6822(84)90268-x.
10
Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.两例人肺癌转化序列的分离：活化的c-K-ras癌基因的结构与功能分析
Proc Natl Acad Sci U S A. 1984 Jan;81(1):71-5. doi: 10.1073/pnas.81.1.71.
Zotero 插件