Mills K R, Edwards R H
Electroencephalogr Clin Neurophysiol. 1984 Apr;57(4):330-5. doi: 10.1016/0013-4694(84)90155-x.
It has been postulated that the power spectral shift in the surface EMG during fatigue is due to accumulation of muscle lactate. This hypothesis has been directly tested by measuring such shift in 3 patients with myophosphorylase deficiency who performed sustained isometric contractions of the quadriceps muscle. It was found that the spectral shift in these patients was greater than that in normal subjects, rendering lactate as a cause of this phenomenon very unlikely. The mechanism of excessive fatiguability in myophosphorylase deficiency is thought to be due to failure of excitation of the muscle membrane; further support for this postulate is provided and it is contended that accumulation of extracellular potassium ions may explain the phenomena of spectral shift in normals and myophosphorylase deficient patients and the excessive fatiguability in the latter.
据推测，疲劳期间表面肌电图的功率谱移位是由于肌肉乳酸堆积所致。通过测量3例肌磷酸化酶缺乏症患者股四头肌持续等长收缩时的这种移位，对这一假说进行了直接验证。结果发现，这些患者的频谱移位大于正常受试者，这使得乳酸不太可能是导致这一现象的原因。肌磷酸化酶缺乏症中过度疲劳的机制被认为是由于肌膜兴奋失败；这一假设得到了进一步支持，有人认为细胞外钾离子的积累可以解释正常人和肌磷酸化酶缺乏症患者的频谱移位现象以及后者的过度疲劳。
