Folgering H, Snik A
Pulmonary Dept., University of Nijmegen, H. Landstichting, The Netherlands.
J Psychosom Res. 1988;32(2):165-71. doi: 10.1016/0022-3999(88)90051-7.
Fatigue is a frequent complaint from patients suffering from the hyperventilation syndrome. Fatigue was quantified in terms of the endurance time that a certain force can be generated in a sustained handgrip contraction, and in terms of the time course of changes in certain parameters of the EMG-power spectrum of the contracting muscles. This was done in a group of 25 normal subjects and a group of 30 patients suffering from the hyperventilation syndrome. No difference in endurance times was found. The EMG-fatiguability in the hyperventilation group developed even slower than in the normal group. In three normals the fatigue parameters were also measured in three conditions of normo-, hypo-, and hyper-capnia. No intraindividual correlations were found between fatigue parameters and CO2-levels. Neither were such correlations found between individuals in the hyperventilation group and the normal group. It is concluded that the subjective feelings of fatigue in the hyperventilation patients cannot be corroborated by the objective measurements used in this study. Thus their fatigue is not of a peripheral type. The levels of CO2 do not have an effect on objectively measured fatigue parameters. The hypothesis that lactate accumulation in contracting muscles mediates EMG-fatiguability, cannot explain the present results, and therefore is not supported by results from this study.
疲劳是患有过度通气综合征患者的常见主诉。通过在持续握力收缩中产生一定力量的耐力时间，以及收缩肌肉肌电图功率谱某些参数的变化时间进程来量化疲劳。在25名正常受试者和30名患有过度通气综合征的患者中进行了此项研究。未发现耐力时间存在差异。过度通气组的肌电图疲劳发展甚至比正常组更慢。在三名正常人中，还在正常碳酸血症、低碳酸血症和高碳酸血症三种条件下测量了疲劳参数。未发现个体内部疲劳参数与二氧化碳水平之间存在相关性。在过度通气组和正常组个体之间也未发现此类相关性。得出的结论是，本研究中使用的客观测量无法证实过度通气患者的主观疲劳感受。因此，他们的疲劳不是外周型的。二氧化碳水平对客观测量的疲劳参数没有影响。收缩肌肉中乳酸积累介导肌电图疲劳的假设无法解释目前的结果，因此本研究结果不支持该假设。
