Sebestík V, Brabec V
Folia Haematol Int Mag Klin Morphol Blutforsch. 1983;110(6):917-23.
Our experiments with rats dealt with finding a possible functional splenic elimination by using an i.v. injection of ethyl and methyl palmitate emulsion. Simultaneously, immunological effects were determined in both substances. After applying ethyl palmitate an extensive splenic necrosis could be induced resulting in an elimination of the sequestrational splenic function to an extent comparable to surgical splenectomy. Histological examinations of liver, lungs, kidneys, heart, bone marrow, lymph nodes and thymus together with the follow-up of some metabolic indicators in the spleen and liver (determination of proteins, DNA, RNA, EFA, transaminases in blood serum and observations of proteosynthesis) showed that the effect of ethyl palmitate on the spleen is selective and that there is no marked damage of other organs. Methyl palmitate is important for its inhibition of antibody response manifesting itself in a reduced production of heteroagglutinins and in a prolonged survival time of skin semiallografts.
我们对大鼠进行的实验旨在通过静脉注射棕榈酸乙酯和甲酯乳液来探寻脾脏可能存在的功能性清除作用。同时，对这两种物质的免疫效应进行了测定。应用棕榈酸乙酯后，可诱发广泛的脾脏坏死，导致脾脏的扣押功能消除，其程度与手术脾切除相当。对肝脏、肺、肾脏、心脏、骨髓、淋巴结和胸腺进行组织学检查，并对脾脏和肝脏中的一些代谢指标进行跟踪（测定血清中的蛋白质、DNA、RNA、必需脂肪酸、转氨酶以及观察蛋白质合成情况），结果表明棕榈酸乙酯对脾脏的作用具有选择性，且对其他器官无明显损害。棕榈酸甲酯因其对抗体反应的抑制作用而具有重要意义，这表现为异凝集素产生减少以及皮肤半同种异体移植存活时间延长。
