免疫球蛋白的免疫原性和抗原表位。VIII. 一种对由组氨酸/精氨酸互换作为免疫球蛋白G第435位残基所确定的不连续表位具有特异性的人单克隆类风湿因子。
Immunogenic and antigenic epitopes of immunoglobulins. VIII. A human monoclonal rheumatoid factor having specificity for a discontinuous epitope determined by histidine/arginine interchange as residue 435 of immunoglobulin G.
作者信息
Jefferis R, Nik Jaafar M I, Steinitz M
出版信息
Immunol Lett. 1984;7(4):191-4. doi: 10.1016/0165-2478(84)90042-7.
PMID:6200430
Abstract
A monoclonal human rheumatoid factor (RF-AN) reactive with human Fc gamma is shown to recognise a discontinuous epitope dependent on the presence of histidine (His) at residue 435. RF-AN is not reactive with IgG1 paraproteins having C gamma 2 or C gamma 3 domain deletions or IgG3m (5) or Ig3m (21) proteins having arginine (Arg) at residue 435. RF-AN is reactive with IgG1, 2, 4 and IgG3m (15,16) proteins having histidine at 435.
摘要
一种与人类Fcγ反应的单克隆人类类风湿因子（RF-AN）被证明可识别一个依赖于435位残基处组氨酸（His）存在的不连续表位。RF-AN与具有Cγ2或Cγ3结构域缺失的IgG1副蛋白或在435位残基处具有精氨酸（Arg）的IgG3m(5)或Ig3m(21)蛋白无反应。RF-AN与在435位具有组氨酸的IgG1、2、4和IgG3m(15,16)蛋白有反应。
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