干扰素在体内诱导自然杀伤细胞母细胞形成。
Interferon induces natural killer cell blastogenesis in vivo.
作者信息
Biron C A, Sonnenfeld G, Welsh R M
出版信息
J Leukoc Biol. 1984 Jan;35(1):31-7. doi: 10.1002/jlb.35.1.31.
PMID:6200554
Abstract
Interferon (IFN), types beta and gamma, and IFN inducers polyinosinic-polycytidylic acid and lymphocytic choriomeningitis virus all stimulated the generation of blast-NK cells in mouse spleens. Blast-NK cells were characterized on the basis of size, 3H-thymidine uptake, and NK cell markers. These data indicate that in addition to augmenting NK cell-mediated lysis, IFN may regulate NK cell proliferation in vivo.
摘要
β型和γ型干扰素以及干扰素诱导剂聚肌苷酸-聚胞苷酸和淋巴细胞性脉络丛脑膜炎病毒均刺激小鼠脾脏中母细胞化自然杀伤细胞（blast-NK细胞）的生成。根据细胞大小、3H-胸腺嘧啶核苷摄取量和自然杀伤细胞标志物对blast-NK细胞进行了鉴定。这些数据表明，干扰素除了增强自然杀伤细胞介导的细胞溶解作用外，还可能在体内调节自然杀伤细胞的增殖。
Zotero 插件