α和γ干扰素以及细胞抑制剂对肾包膜下移植法中卵巢癌的作用。
Effects of alpha and gamma interferons and cytostatics on ovarian cancer in the subrenal capsule assay.
作者信息
Grönroos M, Mäenpää J, Söderström K O, Kangas L, Leppänen M, Cantell K
出版信息
Med Biol. 1983;61(5):275-9.
Ovarian cancers from seven patients were grown in the subrenal capsule assay for 6 days in normal mice and for 12 days in nude mice. Groups of 5 mice received the following daily treatments: 1) saline 2) 6 x 10(5)IU of human leukocyte interferon (IFN-alpha) 3) 3 x 10(3)U of human IFN-gamma 4) 6 x 10(5)IU of IFN-alpha and 3 x 10(3)U of IFN-gamma 5) cytostatic drug combination (doxorubicin, cyclophosphamide, cis-platinum). The cytostatic drug combination had stronger antitumor activity than the interferons. The combination of alpha and gamma interferons was more effective than either interferons alone. The same trend was seen both in normal and nude mice.
将7名患者的卵巢癌在正常小鼠的肾包膜下试验中培养6天，在裸鼠中培养12天。每组5只小鼠接受以下每日治疗：1）生理盐水；2）6×10⁵国际单位的人白细胞干扰素（IFN-α）；3）3×10³单位的人IFN-γ；4）6×10⁵国际单位的IFN-α和3×10³单位的IFN-γ；5）细胞毒性药物组合（阿霉素、环磷酰胺、顺铂）。细胞毒性药物组合的抗肿瘤活性比干扰素更强。α干扰素和γ干扰素联合使用比单独使用任何一种干扰素都更有效。在正常小鼠和裸鼠中都观察到了相同的趋势。
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