Davies P J, Murtaugh M P
Mol Cell Biochem. 1984;58(1-2):69-77. doi: 10.1007/BF00240606.
The function of intracellular transglutaminases remains to be clarified. In fibroblasts the links between the activity of this enzyme and receptor-mediated endocytosis are complex and open to interpretation. However, the issue cannot be firmly laid to rest until the structural specificity of the alkylamine inhibitors of endocytosis is explained. In macrophages, there is substantial evidence that the enzyme plays some role in receptor-mediated phagocytosis, but what this role is and how it might relate to endocytosis in other types of cells is at present an unresolved issue.
细胞内转谷氨酰胺酶的功能仍有待阐明。在成纤维细胞中，这种酶的活性与受体介导的内吞作用之间的联系复杂且有待解读。然而，在内吞作用的烷基胺抑制剂的结构特异性得到解释之前，这个问题无法彻底解决。在巨噬细胞中，有大量证据表明该酶在受体介导的吞噬作用中发挥了一定作用，但目前其作用是什么以及它与其他类型细胞中的内吞作用可能有何关联仍是一个未解决的问题。
