锂对中缝刺激所产生的前脑5-羟吲哚乙酸增加的影响。
The effect of lithium on the increase in forebrain 5-hydroxyindoleacetic acid produced by raphe stimulation.
作者信息
Collard K J
出版信息
Br J Pharmacol. 1978 Jan;62(1):137-42. doi: 10.1111/j.1476-5381.1978.tb07016.x.
Abstract
1 The change in forebrain 5-hydroxyindoleacetic acid (5-HIAA) concentration induced by raphe stimulation has been studied in rats treated with Li+ or 0.9% w/v NaCl solution (saline) for 10 days. 2 Raphe stimulation increased the forebrain concentration of 5-HIAA in both groups of animals. Chlorimipramine abolished this effect in the control group, but not in the Li+ group. 3 The inhibition of 5-hydroxytryptamine (5-HT) uptake by chlorimipramine was not affected by pretreatment with Li+ or by the addition of Li+ to synaptosomal suspensions in vitro. 4 It is suggested that the production of 5-HIAA following raphe stimulation in Li+-treated animals is derived from the metabolism of 5-HT which remains within the intracellular environment. The consequence of this in relation to transmitter release is discussed.
摘要
- 研究了用锂离子或0.9% w/v氯化钠溶液（生理盐水）处理10天的大鼠中，中缝刺激诱导的前脑5-羟吲哚乙酸（5-HIAA）浓度变化。2. 中缝刺激使两组动物的前脑5-HIAA浓度升高。氯米帕明消除了对照组的这种效应，但在锂离子组中未消除。3. 氯米帕明对5-羟色胺（5-HT）摄取的抑制作用不受锂离子预处理或体外向突触体悬浮液中添加锂离子的影响。4. 提示在锂离子处理的动物中，中缝刺激后5-HIAA的产生源自细胞内环境中剩余的5-HT的代谢。讨论了这与神经递质释放相关的后果。
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