一些影响前脑5-羟吲哚-3-乙酸释放的因素。

Some factors influencing the release of 5-hydroxyindol-3-ylacetic acid in the forebrain.

作者信息

Padjen A, Randić M

出版信息

Br J Pharmacol. 1970 May;39(1):1-8. doi: 10.1111/j.1476-5381.1970.tb09550.x.

DOI:10.1111/j.1476-5381.1970.tb09550.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1702980/

Abstract

Electrical stimulation of the mid-brain raphé in anaesthetized adrenalectomized rats produced a significant decrease in the forebrain content of 5-hydroxytryptamine (5-HT) and an increase in the concentration of 5-hydroxyindol-3-ylacetic acid (5-HIAA).2. Stimulation of peripheral sensory nerves did not influence either the forebrain content of 5-HIAA or the efflux of 5-HIAA from the cerebral cortex.3. Probenecid (200 mg/kg) caused a twofold increase in 5-HIAA content of the rat's forebrain, while the efflux of 5-HIAA from the cerebral cortex remained unchanged.4. Stimulation of the mid-brain raphé in animals pretreated with probenecid does not produce the rise in the forebrain levels of 5-HIAA seen in stimulated untreated controls and does not affect the efflux of 5-HIAA from the cerebral cortex.5. In preliminary experiments, lysergic acid diethylamide (LSD 25) substantially reduced and/or prevented the increase in the release of 5-HIAA in the forebrain observed in untreated animals with raphé stimulation.

摘要

对麻醉的肾上腺切除大鼠的中脑缝际进行电刺激，可使前脑5-羟色胺（5-HT）含量显著降低，5-羟吲哚-3-乙酸（5-HIAA）浓度升高。
刺激外周感觉神经对前脑5-HIAA含量或5-HIAA从大脑皮层的流出均无影响。
丙磺舒（200毫克/千克）使大鼠前脑5-HIAA含量增加两倍，而5-HIAA从大脑皮层的流出保持不变。
对用丙磺舒预处理的动物进行中脑缝际刺激，不会像未处理的受刺激对照动物那样使前脑5-HIAA水平升高，也不影响5-HIAA从大脑皮层的流出。
在初步实验中，麦角酸二乙酰胺（LSD 25）可大幅降低和/或阻止在未处理的经缝际刺激动物中观察到的前脑5-HIAA释放增加。