脉冲和稳态标记以及放线菌素D追踪未感染的HeLa细胞中对5,6-二氯-1-β-D-呋喃核糖基苯并咪唑（DRB）具有抗性的核不均一RNA（hnRNA）。
Pulse and steady-state labelled and actinomycin D chased 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB)-resistant hnRNA from uninfected HeLa cells.
作者信息
Brysch B
出版信息
Acta Biochim Pol. 1983;30(3-4):311-24.
PMID:6201028
Abstract
The fraction of hnRNA synthesized in the presence of DRB in uninfected HeLa cells ranges in size from 4S to over 45S. High molecular weight DRB-resistant hnRNA has been demonstrated to decay after 2 h of actinomycin D chase. This fraction is composed of both poly(A)(+) and poly(A)(-) RNA molecules. The synthesis in the presence of DRB of short polyadenylated hnRNA was also observed. The nature of both hnRNA subfractions is discussed.
摘要
在未感染的HeLa细胞中，于DRB存在的情况下合成的核不均一RNA（hnRNA）片段大小范围从4S到超过45S。高分子量的DRB抗性hnRNA已被证明在放线菌素D追踪2小时后会降解。该片段由多聚腺苷酸（poly(A)）阳性和多聚腺苷酸阴性RNA分子组成。还观察到了在DRB存在的情况下短的多聚腺苷酸化hnRNA的合成。对这两种hnRNA亚组分的性质进行了讨论。
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