农药西维因对干扰素合成的抑制作用是增强金鱼病毒2复制的一种机制。
Suppression of interferon synthesis by the pesticide carbaryl as a mechanism for enhancement of goldfish virus-2 replication.
作者信息
Shea T B, Berry E S
出版信息
Appl Environ Microbiol. 1984 Feb;47(2):250-2. doi: 10.1128/aem.47.2.250-252.1984.
Abstract
Interferon production was demonstrated by the goldfish-derived CAR cell line in response to infection by goldfish virus-2. Supernatants of infected cultures provided antiviral protection to CAR cells and another cell line derived from goldfish, ABIII. The protective factor retained activity after ultracentrifugation, dialysis, freezing and thawing, acid treatment (pH 2), or heating to 56 degrees C but was sensitive to trypsin. Supernatants of infected cultures did not affect adsorption of virus. Previous studies have shown that replication of goldfish virus type 2 is enhanced by pretreatment of cultures with subcytotoxic concentrations of carbaryl. In the present study, pesticide-treated cultures were found to synthesize reduced levels of interferon.
摘要
金鱼来源的CAR细胞系在受到金鱼病毒-2感染时可产生干扰素。受感染培养物的上清液为CAR细胞和另一种金鱼来源的细胞系ABIII提供了抗病毒保护。该保护因子在超速离心、透析、冻融、酸处理（pH 2）或加热至56摄氏度后仍保持活性，但对胰蛋白酶敏感。受感染培养物的上清液不影响病毒的吸附。先前的研究表明，用亚细胞毒性浓度的西维因预处理培养物可增强2型金鱼病毒的复制。在本研究中，发现用农药处理的培养物合成的干扰素水平降低。
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