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1
Hapten-specific B cell blockade of the immune response to a thymus-independent-1 antigen produced by concomitant administration of a thymus-independent-2 antigen.通过同时给予胸腺非依赖性-2抗原所产生的对胸腺非依赖性-1抗原免疫应答的半抗原特异性B细胞阻断。
Immunology. 1984 May;52(1):87-96.
2
Characterization of immunogenic properties of haptenated liposomal model membranes in mice. VII. Synergistic responses to haptenated liposomes and haptenated thymus-dependent antigens in CBA/N mice.小鼠中半抗原化脂质体模型膜免疫原性特性的表征。VII. CBA/N小鼠对半抗原化脂质体和半抗原化胸腺依赖性抗原的协同反应。
Immunology. 1982 Apr;45(4):613-20.
3
In vitro studies of the genetically determined unresponsiveness to thymus-independent antigens in CBA/N mice.对CBA/N小鼠中与胸腺非依赖性抗原的基因决定无反应性的体外研究。
J Immunol. 1976 Feb;116(2):301-4.
4
Synergistic effects of the xid gene in X chromosome congenic mice. I. Inability of C3.CBA/N mice to respond to thymus-dependent antigens in adoptive transfer assays.X染色体同源基因小鼠中xid基因的协同效应。I. C3.CBA/N小鼠在过继转移试验中对胸腺依赖性抗原无反应能力。
J Immunol. 1987 Mar 1;138(5):1363-71.
5
A reappraisal of "T-independent" antigens. II. Studies on single, hapten-specific B cells from neonatal CBA/H or CBA/N mice fail to support classification into TI-1 and TI-2 categories.对“非T细胞依赖性”抗原的重新评估。II. 对新生CBA/H或CBA/N小鼠中单个半抗原特异性B细胞的研究未能支持将其分类为TI-1和TI-2类别。
J Immunol. 1984 Apr;132(4):1696-701.
6
A reappraisal of "T-independent" antigens. I. Effect of lymphokines on the response of single adult hapten-specific B lymphocytes.对“非胸腺依赖性”抗原的重新评估。I. 淋巴因子对单个成年半抗原特异性B淋巴细胞反应的影响。
J Immunol. 1984 Apr;132(4):1687-95.
7
Regulation of thymus-independent responses: unresponsiveness to a second challenge of TNP-Ficoll is mediated by hapten-specific antibodies.非胸腺依赖性反应的调节：对半抗原特异性抗体介导的三硝基苯 - 聚蔗糖第二次刺激无反应性。
J Immunol. 1980 Oct;125(4):1499-505.
8
In vitro responses of CBA/N mice: spleen cells of mice with an X-linked defect that precludes immune responses to several thymus-independent antigens can respond to TNP-lipopolysaccharide.CBA/N小鼠的体外反应：具有X连锁缺陷、无法对多种胸腺非依赖性抗原产生免疫反应的小鼠的脾细胞，能够对三硝基苯-脂多糖产生反应。
J Immunol. 1976 Oct;117(4):1363-9.
9
Characterization of immunogenic properties of haptenated liposomal model membranes in mice. VI. Response in B-cell-defective CBA/N mice.小鼠中半抗原化脂质体模型膜免疫原性特性的表征。VI. B细胞缺陷型CBA/N小鼠的反应。
Immunology. 1982 Mar;45(3):545-51.
10
In vitro analysis of allogeneic lymphocyte interaction. VIII. Characterization of helper components of allogeneic effect factor (AEF) that activate Lyb5+ and Lyb5- B cells to respond to thymus-dependent and thymus-independent antigens.同种异体淋巴细胞相互作用的体外分析。VIII. 激活Lyb5 +和Lyb5 - B细胞以响应胸腺依赖性和胸腺非依赖性抗原的同种异体效应因子（AEF）辅助成分的特征。
J Immunol. 1983 Nov;131(5):2246-53.

本文引用的文献

1
B cell tolerance induced by polymeric antigens. III. Dissociation of antibody formation and memory generation in tolerant mice.多聚抗原诱导的B细胞耐受性。III. 耐受性小鼠中抗体形成与记忆产生的解离
Eur J Immunol. 1975 Oct;5(10):699-704. doi: 10.1002/eji.1830051010.
2
Tolerogenic or immunogenic activity of hapten-conjugated polysaccharides correlated with cellular localization.半抗原偶联多糖的耐受性或免疫原性活性与细胞定位相关。
Eur J Immunol. 1981 Mar;11(3):212-20. doi: 10.1002/eji.1830110310.
3
Lyb antigens and their role in B lymphocyte activation.Lyb抗原及其在B淋巴细胞激活中的作用。
Immunol Rev. 1982;69:81-97. doi: 10.1111/j.1600-065x.1983.tb00450.x.
4
Characterization of immunogenic properties of haptenated liposomal model membranes in mice. VII. Synergistic responses to haptenated liposomes and haptenated thymus-dependent antigens in CBA/N mice.小鼠中半抗原化脂质体模型膜免疫原性特性的表征。VII. CBA/N小鼠对半抗原化脂质体和半抗原化胸腺依赖性抗原的协同反应。
Immunology. 1982 Apr;45(4):613-20.
5
Characterization of immunogenic properties of haptenated liposomal model membranes in mice. VI. Response in B-cell-defective CBA/N mice.小鼠中半抗原化脂质体模型膜免疫原性特性的表征。VI. B细胞缺陷型CBA/N小鼠的反应。
Immunology. 1982 Mar;45(3):545-51.
6
Chemical, physical, biological properties of a lipopolysaccharide from Escherichia coli K-235.大肠杆菌K-235脂多糖的化学、物理和生物学性质
Biochemistry. 1967 Aug;6(8):2363-72. doi: 10.1021/bi00860a011.
7
Synthesis of large haptenic compounds having a common functional group that permits covalent linkage to proteins, cell surfaces, and adsorbents.具有共同官能团的大型半抗原化合物的合成，该官能团允许与蛋白质、细胞表面和吸附剂进行共价连接。
Immunochemistry. 1973 Mar;10(3):153-63. doi: 10.1016/0019-2791(73)90004-9.
8
Coupling of large haptens to proteins and cell surfaces: preparation of stable, optimally sensitized erythrocytes for hapten-specific, hemolytic plaque assays.大分子半抗原与蛋白质及细胞表面的偶联：制备用于半抗原特异性溶血空斑试验的稳定、最佳致敏红细胞。
Immunochemistry. 1973 Mar;10(3):165-74. doi: 10.1016/0019-2791(73)90005-0.
9
Genetic control of the antibody response to type 3 pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness.小鼠对3型肺炎球菌多糖抗体反应的遗传控制。I. 有证据表明一个X连锁基因在决定反应性方面起决定性作用。
J Exp Med. 1972 Oct 1;136(4):931-49. doi: 10.1084/jem.136.4.931.
10
Structural and genetic basis of the in vivo immune response to TNP-LPS.对三硝基苯脂多糖（TNP-LPS）体内免疫反应的结构和遗传基础
J Immunol. 1975 Oct;115(4):988-92.

通过同时给予胸腺非依赖性-2抗原所产生的对胸腺非依赖性-1抗原免疫应答的半抗原特异性B细胞阻断。

Hapten-specific B cell blockade of the immune response to a thymus-independent-1 antigen produced by concomitant administration of a thymus-independent-2 antigen.

作者信息

Snippe H, Van Houte A J, Inman J K, Lizzio E F, Merchant B

出版信息

Immunology. 1984 May;52(1):87-96.

PMID:6201438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1454594/
Abstract

CBA/N mice harbour an X-linked B cell defect which is transmitted by CBA/N female mice to their hybrid male progeny. These mice mount normal responses to thymus-dependent (TD) and some thymus-independent (TI-1) antigens, while the response to TI-2 antigens is absent. Hapten-specific plaque-forming cell (PFC) responses to TD antigens can be blockaded by concomitant exposure of these mice to TI-2 antigens bearing the same hapten. This paper investigates in defective mice the blockade of their response to TNP3-LPS (trinitrophenylated lipopolysaccharide, a TI-1 antigen), imposed by DNP59-Ficoll (dinitrophenylated Ficoll, a TI-2 antigen). The effectiveness of the blocking agent, DNP59-Ficoll, differed in various inbred mouse strains: CBA/N X C3H/HeN F1 male greater than CBA/N female greater than CBA/N X C3H/HeN F1 female. The role of T cells in the observed hapten-specific blockade phenomenon was investigated using athymic CBA/N nude mice and a B cell tolerogen. Our findings indicate that T cell participation is not essential for the blockade of CBA/N PFC responses and they suggest that direct blockade of TI- and TD-responsive B cell populations is likely to occur.

摘要

CBA/N小鼠存在一种X连锁的B细胞缺陷，该缺陷由CBA/N雌性小鼠传递给它们的杂交雄性后代。这些小鼠对胸腺依赖性（TD）抗原和一些胸腺非依赖性（TI-1）抗原产生正常反应，而对TI-2抗原则无反应。对TD抗原的半抗原特异性空斑形成细胞（PFC）反应可被这些小鼠同时暴露于带有相同半抗原的TI-2抗原所阻断。本文研究了在缺陷小鼠中，由DNP59-菲可（二硝基苯基化菲可，一种TI-2抗原）对其对TNP3-LPS（三硝基苯基化脂多糖，一种TI-1抗原）反应的阻断作用。阻断剂DNP59-菲可在不同近交系小鼠中的效果不同：CBA/N×C3H/HeN F1雄性大于CBA/N雌性大于CBA/N×C3H/HeN F1雌性。使用无胸腺的CBA/N裸鼠和一种B细胞耐受原研究了T细胞在观察到的半抗原特异性阻断现象中的作用。我们的研究结果表明，T细胞参与对于CBA/N PFC反应的阻断并非必不可少，并且提示TI和TD反应性B细胞群体可能发生直接阻断。