相似文献

1

Hapten-specific B cell blockade of the immune response to a thymus-independent-1 antigen produced by concomitant administration of a thymus-independent-2 antigen.

Immunology. 1984 May;52(1):87-96.

2

Characterization of immunogenic properties of haptenated liposomal model membranes in mice. VII. Synergistic responses to haptenated liposomes and haptenated thymus-dependent antigens in CBA/N mice.

Immunology. 1982 Apr;45(4):613-20.

3

In vitro studies of the genetically determined unresponsiveness to thymus-independent antigens in CBA/N mice.

J Immunol. 1976 Feb;116(2):301-4.

4

Synergistic effects of the xid gene in X chromosome congenic mice. I. Inability of C3.CBA/N mice to respond to thymus-dependent antigens in adoptive transfer assays.

J Immunol. 1987 Mar 1;138(5):1363-71.

5

A reappraisal of "T-independent" antigens. II. Studies on single, hapten-specific B cells from neonatal CBA/H or CBA/N mice fail to support classification into TI-1 and TI-2 categories.

J Immunol. 1984 Apr;132(4):1696-701.

6

A reappraisal of "T-independent" antigens. I. Effect of lymphokines on the response of single adult hapten-specific B lymphocytes.

J Immunol. 1984 Apr;132(4):1687-95.

7

Regulation of thymus-independent responses: unresponsiveness to a second challenge of TNP-Ficoll is mediated by hapten-specific antibodies.

J Immunol. 1980 Oct;125(4):1499-505.

8

In vitro responses of CBA/N mice: spleen cells of mice with an X-linked defect that precludes immune responses to several thymus-independent antigens can respond to TNP-lipopolysaccharide.

J Immunol. 1976 Oct;117(4):1363-9.

9

Characterization of immunogenic properties of haptenated liposomal model membranes in mice. VI. Response in B-cell-defective CBA/N mice.

Immunology. 1982 Mar;45(3):545-51.

10

In vitro analysis of allogeneic lymphocyte interaction. VIII. Characterization of helper components of allogeneic effect factor (AEF) that activate Lyb5+ and Lyb5- B cells to respond to thymus-dependent and thymus-independent antigens.

J Immunol. 1983 Nov;131(5):2246-53.

本文引用的文献

1

B cell tolerance induced by polymeric antigens. III. Dissociation of antibody formation and memory generation in tolerant mice.

Eur J Immunol. 1975 Oct;5(10):699-704. doi: 10.1002/eji.1830051010.

2

Tolerogenic or immunogenic activity of hapten-conjugated polysaccharides correlated with cellular localization.

Eur J Immunol. 1981 Mar;11(3):212-20. doi: 10.1002/eji.1830110310.

3

Lyb antigens and their role in B lymphocyte activation.

Immunol Rev. 1982;69:81-97. doi: 10.1111/j.1600-065x.1983.tb00450.x.

4

Characterization of immunogenic properties of haptenated liposomal model membranes in mice. VII. Synergistic responses to haptenated liposomes and haptenated thymus-dependent antigens in CBA/N mice.

Immunology. 1982 Apr;45(4):613-20.

5

Characterization of immunogenic properties of haptenated liposomal model membranes in mice. VI. Response in B-cell-defective CBA/N mice.

Immunology. 1982 Mar;45(3):545-51.

6

Chemical, physical, biological properties of a lipopolysaccharide from Escherichia coli K-235.

Biochemistry. 1967 Aug;6(8):2363-72. doi: 10.1021/bi00860a011.

7

Synthesis of large haptenic compounds having a common functional group that permits covalent linkage to proteins, cell surfaces, and adsorbents.

Immunochemistry. 1973 Mar;10(3):153-63. doi: 10.1016/0019-2791(73)90004-9.

8

Coupling of large haptens to proteins and cell surfaces: preparation of stable, optimally sensitized erythrocytes for hapten-specific, hemolytic plaque assays.

Immunochemistry. 1973 Mar;10(3):165-74. doi: 10.1016/0019-2791(73)90005-0.

9

Genetic control of the antibody response to type 3 pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness.

J Exp Med. 1972 Oct 1;136(4):931-49. doi: 10.1084/jem.136.4.931.

10

Structural and genetic basis of the in vivo immune response to TNP-LPS.

J Immunol. 1975 Oct;115(4):988-92.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。

通过同时给予胸腺非依赖性-2抗原所产生的对胸腺非依赖性-1抗原免疫应答的半抗原特异性B细胞阻断。

Hapten-specific B cell blockade of the immune response to a thymus-independent-1 antigen produced by concomitant administration of a thymus-independent-2 antigen.

作者信息

Snippe H, Van Houte A J, Inman J K, Lizzio E F, Merchant B

出版信息

Immunology. 1984 May;52(1):87-96.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1454594/

Abstract

CBA/N mice harbour an X-linked B cell defect which is transmitted by CBA/N female mice to their hybrid male progeny. These mice mount normal responses to thymus-dependent (TD) and some thymus-independent (TI-1) antigens, while the response to TI-2 antigens is absent. Hapten-specific plaque-forming cell (PFC) responses to TD antigens can be blockaded by concomitant exposure of these mice to TI-2 antigens bearing the same hapten. This paper investigates in defective mice the blockade of their response to TNP3-LPS (trinitrophenylated lipopolysaccharide, a TI-1 antigen), imposed by DNP59-Ficoll (dinitrophenylated Ficoll, a TI-2 antigen). The effectiveness of the blocking agent, DNP59-Ficoll, differed in various inbred mouse strains: CBA/N X C3H/HeN F1 male greater than CBA/N female greater than CBA/N X C3H/HeN F1 female. The role of T cells in the observed hapten-specific blockade phenomenon was investigated using athymic CBA/N nude mice and a B cell tolerogen. Our findings indicate that T cell participation is not essential for the blockade of CBA/N PFC responses and they suggest that direct blockade of TI- and TD-responsive B cell populations is likely to occur.

摘要

CBA/N小鼠存在一种X连锁的B细胞缺陷，该缺陷由CBA/N雌性小鼠传递给它们的杂交雄性后代。这些小鼠对胸腺依赖性（TD）抗原和一些胸腺非依赖性（TI-1）抗原产生正常反应，而对TI-2抗原则无反应。对TD抗原的半抗原特异性空斑形成细胞（PFC）反应可被这些小鼠同时暴露于带有相同半抗原的TI-2抗原所阻断。本文研究了在缺陷小鼠中，由DNP59-菲可（二硝基苯基化菲可，一种TI-2抗原）对其对TNP3-LPS（三硝基苯基化脂多糖，一种TI-1抗原）反应的阻断作用。阻断剂DNP59-菲可在不同近交系小鼠中的效果不同：CBA/N×C3H/HeN F1雄性大于CBA/N雌性大于CBA/N×C3H/HeN F1雌性。使用无胸腺的CBA/N裸鼠和一种B细胞耐受原研究了T细胞在观察到的半抗原特异性阻断现象中的作用。我们的研究结果表明，T细胞参与对于CBA/N PFC反应的阻断并非必不可少，并且提示TI和TD反应性B细胞群体可能发生直接阻断。