Jacobs D M
J Immunol. 1975 Oct;115(4):988-92.
TNP-lipopolysaccharide (TNP-LPS) is a potent T-independent antigen in vivo, inducing a TNP-PFC response in T-depleted animals. The structural integrity of the lipid A-KDO portion of the LPS carrier molecule appears to be required since the haptenated LPS from Salmonella minnesota Re595 is immunogenic whereas the haptenated derivative of base hydrolyzed LPS is not. The immune response is not associated with any of the common histocompatiblity types, but does depend on the ability of the host strain to respond to LPS. C3H/HeJ mice are not killed by low doses of LPS and give a poor PFC response to TNP-LPS. Lethality and immunogenicity are dominant responses in hybrids of C3H/HeJ and responder mice. The structural and genetic requirements for the response to TNP-LPS suggest an active role for the carrier in the immunogenicity of this T-independent antigen.
三硝基苯-脂多糖（TNP-LPS）在体内是一种有效的非T细胞依赖性抗原，可在T细胞缺失的动物中诱导TNP-浆细胞前体（PFC）反应。LPS载体分子的脂质A-KDO部分的结构完整性似乎是必需的，因为来自明尼苏达沙门氏菌Re595的半抗原化LPS具有免疫原性，而碱水解LPS的半抗原化衍生物则没有。免疫反应与任何常见的组织相容性类型均无关，但确实取决于宿主菌株对LPS的反应能力。低剂量的LPS不会杀死C3H/HeJ小鼠，并且它们对TNP-LPS的PFC反应较差。在C3H/HeJ和反应性小鼠的杂交后代中，致死性和免疫原性是显性反应。对TNP-LPS反应的结构和遗传要求表明载体在这种非T细胞依赖性抗原的免疫原性中起积极作用。
