Katoh K, Murai K, Nonoyama T
Res Vet Sci. 1984 Mar;36(2):147-52.
The effects of substance P on fluid and amylase secretion were examined in the exocrine pancreas of the rat and the mouse in vivo and in vitro. In the anaesthetised rat, a single intravenous injection of substance P caused an atropine resistant increase in both the basal and caerulein stimulated flow of pancreatic juice and amylase output, but reduced the secretin stimulated pancreatic juice flow. In vitro experiments using superfused mouse pancreatic fragments supported the in vivo result showing that substance P enhanced caerulein stimulated amylase output.
在大鼠和小鼠体内及体外，研究了P物质对其外分泌胰腺中液体和淀粉酶分泌的影响。在麻醉的大鼠中，单次静脉注射P物质会导致基础和蛙皮素刺激的胰液分泌及淀粉酶分泌量出现阿托品抵抗性增加，但会减少促胰液素刺激的胰液分泌。使用灌流的小鼠胰腺片段进行的体外实验支持了体内实验结果，表明P物质增强了蛙皮素刺激的淀粉酶分泌。
