Totkova A M
Ukr Biokhim Zh (1978). 1984 Mar-Apr;56(2):157-61.
It is found that serotonin content in the brain areas and heart of rats with low alcohol motivation decreases after 5 months of chronic consumption of 48% ethanol solution in a dose of 4 g/kg; in animals with high alcohol motivation serotonin content decreases only in the hypothalamus. Under chronic alcoholization for 1 and 12 months no considerable changes were found in serotonin level of the studied tissues. 60 min after intraperitoneal administration of 20% ethanol solution in a dose of 3 g/kg in intact animals there occurs an increase of serotonin content in the brain hemispheres and heart and its decrease in the hypothalamus; in rat with low alcohol motivation after taking ethanol for 5 months this administration evokes a decrease of serotonin content in the hypothalamus and truncus cerebri; in rats with high alcohol motivation--its decrease in the hypothalamus. Excretion of 5-oxyindoleacetic acid with urine decreases 10 months after alcohol intoxication. When rats were not given ethanol after its chronic taking for 3 months serotonin oxidation was intensified for the first day, which was not observed after 7-month alcoholization of animals.
研究发现，低酒精动机的大鼠在以4克/千克的剂量长期饮用48%乙醇溶液5个月后，其大脑区域和心脏中的血清素含量会降低；高酒精动机的动物血清素含量仅在下丘脑降低。在慢性酒精化1个月和12个月时，所研究组织的血清素水平未发现明显变化。在完整动物腹腔注射3克/千克剂量的20%乙醇溶液60分钟后，大脑半球和心脏中的血清素含量增加，而下丘脑的血清素含量降低；低酒精动机的大鼠在饮用乙醇5个月后，这种给药方式会导致下丘脑和脑干中的血清素含量降低；高酒精动机的大鼠——其血清素在下丘脑降低。酒精中毒10个月后，尿中5-羟吲哚乙酸的排泄量减少。在大鼠连续3个月长期饮用乙醇后停止给予乙醇，血清素氧化在第一天增强，而在动物酒精化7个月后未观察到这种情况。
