Alomran A, Shenton B K, Donnelly P K, Francis D M, Proud G, Taylor R M
Ann N Y Acad Sci. 1983;421:394-7. doi: 10.1111/j.1749-6632.1983.tb18131.x.
Most of the plasma suppressive activity was associated with alpha 2M in both normal subjects and cancer patients. alpha 2M binding to physiological levels of proteases was associated with an increase in the ability to suppress lymphocyte reactivity in the TEEM test. alpha 2M binding to proteases released a peptide that was a component of the alpha 2M; this peptide suppressed lymphocyte reactivity to mitogenic, antigenic, and allogenic stimuli in the TEEM test and in the lymphocyte transformation assay. Physically and biologically similar peptides have been found in the plasma of cancer patients and patients with thermal burns, uremia, and acute pancreatitis.
在正常受试者和癌症患者中，大部分血浆抑制活性都与α2M相关。α2M与生理水平的蛋白酶结合，与TEEM试验中抑制淋巴细胞反应性的能力增强有关。α2M与蛋白酶结合会释放出一种肽，该肽是α2M的一个组成部分；这种肽在TEEM试验和淋巴细胞转化试验中抑制淋巴细胞对有丝分裂原、抗原和同种异体刺激的反应。在癌症患者以及热烧伤、尿毒症和急性胰腺炎患者的血浆中发现了物理和生物学性质相似的肽。
