Brûlé G, Haudecoeur G, Jdâïaa H, Guilbault P
Arch Int Physiol Biochim. 1983 Nov;91(4):269-77. doi: 10.3109/13813458309067974.
Agents such as TEA+ or CS+ ions, these last ions instead of K+ ions in poor K extracellular solution, known to reduce or abolish the inwardly rectifying channel in many preparations produced no effect in crayfish muscle membrane By contrast, poor Cl extracellular solution (Cl- ions were replaced by CH3OSO3- ions) blocked the inward current activated by hyperpolarizing pulses and produced an increase of the resting potential. Niflumic acid is a agent which inhibited the inward going rectification of the crayfish muscle membrane. Apparent dissociation constant of niflumic acid with membrane sites was equal to about 6 X 10(-8) M; this value corresponds to that given by Cousin & Motais (1979) concerning translocation of Cl- ions in the membrane of red cells. Activation of the inward going rectification in the crayfish membrane is responsible of an inward current carried by Cl- ions.
诸如TEA⁺或CS⁺离子这类物质，在低钾细胞外溶液中，这些离子会取代K⁺离子，已知它们在许多制剂中会减少或消除内向整流通道，但对小龙虾肌肉膜没有影响。相比之下，低氯细胞外溶液（Cl⁻离子被CH₃OSO₃⁻离子取代）会阻断由超极化脉冲激活的内向电流，并使静息电位增加。氟尼辛是一种抑制小龙虾肌肉膜内向整流的物质。氟尼辛与膜位点的表观解离常数约为6×10⁻⁸M；该值与Cousin和Motais（1979年）给出的关于红细胞膜中Cl⁻离子转运的值相对应。小龙虾膜中内向整流的激活是由Cl⁻离子携带的内向电流引起的。
