Andreesen R, Osterholz J, Löhr G W, Bross K J
Blood. 1984 Jun;63(6):1299-302.
A Hodgkin cell-specific antigen detected by the monoclonal antibody Ki-1 was found on T helper lymphocytes after activation by autologous and allogeneic stimulator cells. About 50% of lymphoblasts generated by auto- and alloactivation reacted with the antibody. In contrast, only less than 6% of lymphoblasts stimulated with Con-A, phytohemagglutinin (PHA), or protein A, and none of lymphoblasts activated by oxidative mitogenesis, expressed this antigen. Among several permanent cell lines tested, the K562, MOLT-4, HL-60, and EBV transformed B lymphoblastoid cells reacted with the Ki-1 antibody. The results may indicate possible relationships between the autoreactive subset of T lymphocytes and the pathogenesis of Hodgkin's disease.
一种由单克隆抗体Ki-1检测到的霍奇金细胞特异性抗原，在自体和同种异体刺激细胞激活后的T辅助淋巴细胞上被发现。自体和同种异体激活产生的成淋巴细胞中约50%与该抗体发生反应。相比之下，用刀豆蛋白A、植物血凝素（PHA）或蛋白A刺激产生的成淋巴细胞中，只有不到6%与该抗体发生反应，而通过氧化有丝分裂激活的成淋巴细胞中则无一表达该抗原。在测试的几种永久细胞系中，K562、MOLT-4、HL-60和EB病毒转化的B淋巴母细胞与Ki-1抗体发生反应。这些结果可能表明T淋巴细胞的自身反应性子集与霍奇金病的发病机制之间存在可能的关系。
