Drury M I, Sugrue D D, Drury R M
Clin Exp Obstet Gynecol. 1984;11(3):79-89.
Goitre is common and alterations in biochemical indices of thyroid function are invariable during pregnancy , but thyroid disease, of which hyperthyroidism is the most frequent (0,05% of 72,257 pregnancies at three Dublin Maternity Hospitals, 1979-81) is rare. Good results in terms of perinatal loss (4/112, 3.57%) has been achieved by one of us (MID) in 109 pregnancies using antithyroid drugs alone. Neonatal thyrotoxicosis occurs in one to two percent of babies born to mothers with thyroid disease. The condition is usually transient but a prolonged course may occur in up to 20 percent. Successful pregnancy is possible despite maternal hypothyroidism; three such pregnancies have been managed by one of us (MID). Clinical hyperthyroidism due to trophoblastic disease is very rare and is cured by evacuation of molar tissue. The course of thyroid cancer is not affected by pregnancy.
甲状腺肿很常见，孕期甲状腺功能生化指标的改变也很常见，但甲状腺疾病很少见，其中最常见的是甲状腺功能亢进（1979 - 1981年，都柏林三家妇产医院的72257例妊娠中，占0.05%）。我们中的一人（MID）单用抗甲状腺药物治疗了109例妊娠，围产期损失率（4/112，3.57%）效果良好。患有甲状腺疾病的母亲所生婴儿中，1%至2%会发生新生儿甲状腺毒症。这种情况通常是短暂的，但高达20%的病例可能会病程延长。尽管母亲患有甲状腺功能减退症，成功妊娠也是可能的；我们中的一人（MID）已经处理过3例这样的妊娠。由于滋养层疾病导致的临床甲状腺功能亢进非常罕见，通过清除葡萄胎组织可以治愈。妊娠不影响甲状腺癌的病程。
