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髓鞘相关糖蛋白(MAG)在视神经华勒氏变性中的作用

Myelin associated glycoprotein (MAG) in Wallerian degeneration of the optic nerve.

作者信息

Wender M, Wajgt A, Michałowska G, Tokarz E

出版信息

Exp Pathol. 1984;25(2):125-7. doi: 10.1016/s0232-1513(84)80019-5.

DOI:10.1016/s0232-1513(84)80019-5
PMID:6202545
Abstract

The content of myelin associated glycoprotein (MAG) was studied in the rabbit optic nerves undergoing Wallerian degeneration after ophthalmectomy . MAG was estimated according to the method described by Matthieu and Quarles (1973). The results of the studies demonstrated only negligible changes in the content of MAG in the course of central Wallerian degeneration. These experiments do not support the assumption that the periaxionally localized MAG of the central myelin is as a rule seriously involved in subcellular mechanisms functioning in early stages of central demyelinating processes.

摘要

对眼球摘除术后发生沃勒变性的兔视神经中髓鞘相关糖蛋白(MAG)的含量进行了研究。MAG 是根据 Matthieu 和 Quarles(1973 年)描述的方法进行测定的。研究结果表明,在中枢性沃勒变性过程中,MAG 的含量仅发生了微不足道的变化。这些实验不支持这样一种假设,即中枢髓鞘中轴突周围定位的 MAG 通常会严重参与中枢脱髓鞘过程早期阶段的亚细胞机制运作。

相似文献

1
Myelin associated glycoprotein (MAG) in Wallerian degeneration of the optic nerve.髓鞘相关糖蛋白(MAG)在视神经华勒氏变性中的作用
Exp Pathol. 1984;25(2):125-7. doi: 10.1016/s0232-1513(84)80019-5.
2
Wallerian degeneration of the optic nerve in light of histological and biochemical studies.
Acta Neuropathol Suppl. 1981;7:36-9. doi: 10.1007/978-3-642-81553-9_11.
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Myelin proteins in Wallerian degeneration of the optic nerve.
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Comparison of the distribution of Na+,K+-ATPase and myelin-associated glycoprotein (MAG) in the optic nerve, spinal cord and trigeminal ganglion of shiverer (shi/shi) and control (+/+) mice.颤抖小鼠(shi/shi)和对照小鼠(+/+)视神经、脊髓和三叉神经节中Na +,K + -ATP酶和髓磷脂相关糖蛋白(MAG)分布的比较。
Brain Res. 1987 Jul 7;415(1):105-14. doi: 10.1016/0006-8993(87)90273-3.
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Myelin-associated glycoprotein: electron microscopic immunocytochemical localization in compact developing and adult central nervous system myelin.髓鞘相关糖蛋白:在发育中的致密型和成人中枢神经系统髓鞘中的电子显微镜免疫细胞化学定位
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The loss of neuron-specific proteins during the course of Wallerian degeneration of optic and sciatic nerve.视神经和坐骨神经华勒氏变性过程中神经元特异性蛋白质的丧失。
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Studies on the myelin protein changes and antigenic properties of rabbit sciatic nerves undergoing Wallerian degeneration.兔坐骨神经沃勒变性过程中髓鞘蛋白变化及抗原特性的研究。
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Ultrastructural sequence of myelin degradation. I. Wallerian degeneration in the rat optic nerve.髓鞘降解的超微结构序列。I. 大鼠视神经中的沃勒变性。
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[Biochemical changes in glycerophospholipids, particularly plasmalogen, during an early stage of the Wallerian degeneration of rabbit optic nerves. II. Analysis of degenerative optic nerves (author's transl)].
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[Biochemical changes in glycerophspholipids, particularly plasmalogen, during an early stage of the Wallerian degeneration of rabbit optic nerves. I. The analytical methods and analysis of normal optic nerves (author's transl)].
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Degradation products of myelin proteins in a light CNS subcellular fraction.中枢神经系统轻亚细胞组分中髓鞘蛋白的降解产物
Neurochem Res. 1989 Dec;14(12):1177-80. doi: 10.1007/BF00965505.