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[延髓前庭核团对大鼠脑和小肠5-羟色胺能系统功能的影响]

[Effect of the vestibular nuclei of the medulla oblongata on the serotoninergic system function of the brain and small intestine in the rat].

作者信息

Tropnikova G K

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1984 Mar;70(3):284-90.

PMID:6202562
Abstract

In alert adult female Wistar albino rats, high-frequency stimulation of the Deiters' nuclei with biphasic square pulses via implanted electrodes evoked a significant increase in the serotonin (5-HT) content in the cerebellum, hypothalamus and hippocampus, and a decrease in the striatum with a parallel increase of 5- hydroxiindolacetic acid (5-HIAA) level in the cerebellum, thalamus and spinal cord and its decrease in the parietal cortex. Destruction of the vestibular nuclei, conversely, produced a decrease in the 5-HT content in the hypothalamus, medulla oblongata and spinal cord, as well as 5-HIAA in the thalamus and did not affect the contents of these substances in other areas of the CNS. In contrast to the brain, the duodenum and ileum revealed no considerable changes in the 5-HT or 5-HIAA contents under both influences.

摘要

在清醒的成年雌性Wistar白化大鼠中,通过植入电极用双相方波脉冲对代特氏核进行高频刺激,可使小脑、下丘脑和海马体中的血清素(5-羟色胺,5-HT)含量显著增加,纹状体中的5-HT含量减少,同时小脑、丘脑和脊髓中的5-羟吲哚乙酸(5-HIAA)水平平行升高,而顶叶皮质中的5-HIAA水平降低。相反,破坏前庭核会使下丘脑、延髓和脊髓中的5-HT含量以及丘脑中的5-HIAA含量降低,且不影响中枢神经系统其他区域中这些物质的含量。与大脑不同,十二指肠和回肠在这两种影响下,5-HT或5-HIAA含量均未出现明显变化。

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