Dmitriev A S, Tropnikova G K
Kosm Biol Aviakosm Med. 1988 Jan-Feb;22(1):45-9.
Rat experiments were performed to study variations in serotonin (5-HT) and its metabolite (5-hydroxy indole acetic acid) in different CNS compartments. Control animals were exposed to an acute vibration stress (10 Hz, 1 mm, 2 m/sec2, 15 min) and experimental animals to a prolonged (52-54 days) vibration test. Acute vibration led to 5-HT activation which was most significant in the hippocampus, diencephalon, cerebellum and in the sacrolumbar cord. Prolonged vibration caused an increase of 5-HT in the parietal cortex and its enhanced utilization in the striatum, diencephalon, pons and in the sacrolumbar cord. As compared to the controls, vibration produced a smaller accumulation of 5-HT in the hippocampus and a larger accumulation in the cerebellum, diencephalon, medulla oblongata and spinal cord. The paper discusses the role of regional changes in 5-HT metabolism and reactivity of serotoninergic structures in the mechanism of vibration-related somatosensory disorders.
进行大鼠实验以研究不同中枢神经系统区域中血清素（5-羟色胺，5-HT）及其代谢产物（5-羟基吲哚乙酸）的变化。将对照动物暴露于急性振动应激（10赫兹，1毫米，2米/秒²，15分钟），而将实验动物暴露于长时间（52 - 54天）的振动测试。急性振动导致5-HT激活，这在海马体、间脑、小脑和腰骶脊髓中最为显著。长时间振动导致顶叶皮质中5-HT增加，以及纹状体、间脑、脑桥和腰骶脊髓中5-HT利用率提高。与对照组相比，振动在海马体中产生的5-HT积累较少，而在小脑、间脑、延髓和脊髓中积累较多。本文讨论了5-HT代谢的区域变化以及血清素能结构的反应性在与振动相关的体感障碍机制中的作用。
