Noworolska A, Kościelniak E, Brodzka W, Harłozińska A
Folia Haematol Int Mag Klin Morphol Blutforsch. 1984;111(1):1-7.
Leukemic cells from 32 patients were examined by using conventional immunological markers (E and EAC rosettes, surface immunoglobulins). Additionally, the test for intracytoplasmic IgM, Fc IgG receptor and the presence of light chains were performed. Leukemic blasts of all patients were investigated according to morphological and cytochemical criteria. Lymphoblasts from 3 patients had pre-B cell phenotype: cIgM +, sIg-. Each of 3 patients with pre-B cell characteristics had different diagnosis and different morphological and cytochemical features of the leukemic cells (ALL, NHL and CML). In 24 ALL cases the diagnosis of non-T, non-B ALL, in 4 cases T-ALL and in one B-ALL was established. The correlation of cytochemical results with special reference to acid phosphatase and immunological subclasses of ALL was also analyzed. An important question is raised with regard to diagnostic classification and treatment by finding ALL phenotypes in lymphoproliferative disorders that are not diagnosed as ALL.
运用传统免疫标记物（E和EAC玫瑰花结、表面免疫球蛋白）对32例患者的白血病细胞进行检测。此外，还进行了胞浆内IgM、Fc IgG受体及轻链检测。依据形态学和细胞化学标准对所有患者的白血病原始细胞进行研究。3例患者的淋巴母细胞具有前B细胞表型：胞浆内IgM阳性，表面免疫球蛋白阴性。3例具有前B细胞特征的患者各自诊断不同，白血病细胞的形态学和细胞化学特征也不同（急性淋巴细胞白血病、非霍奇金淋巴瘤和慢性粒细胞白血病）。24例急性淋巴细胞白血病确诊为非T、非B型急性淋巴细胞白血病，4例为T型急性淋巴细胞白血病，1例为B型急性淋巴细胞白血病。还分析了细胞化学结果与特别提及的酸性磷酸酶及急性淋巴细胞白血病免疫亚类的相关性。在未诊断为急性淋巴细胞白血病的淋巴增殖性疾病中发现急性淋巴细胞白血病表型，这对于诊断分类和治疗提出了一个重要问题。
