Gan No Rinsho. 1984 May;30(5):449-54.
A cooperative study was performed to evaluate the effects of bleomycin (BLM) and tegafur (FT) combined with preoperative radiotherapy for esophageal carcinoma. The drug choice was made randomly. A solid form of BLM was administered intraoperatively to two patient groups; there were 18 operative deaths. Death due to pneumonia was significantly high in the BLM group. Cases excluding operative deaths were used to calculate the cumulative survival rate. There was no significant difference in fluoroscopic findings, the age distribution and the extent of the disease. Concerning the radiation effect, histologic study of the resected specimen, showed that more patients in the tegafur group showed a marked effect. This group had a better postoperative survival rate, however, the difference was not significant.
开展了一项合作研究，以评估博来霉素（BLM）和替加氟（FT）联合术前放疗对食管癌的疗效。药物选择是随机进行的。将固体形式的博来霉素术中给予两个患者组；有18例手术死亡。博来霉素组因肺炎导致的死亡显著较高。排除手术死亡的病例用于计算累积生存率。透视检查结果、年龄分布和疾病范围方面无显著差异。关于放射效果，对切除标本的组织学研究表明，替加氟组有更多患者显示出明显效果。该组术后生存率较好，然而，差异并不显著。
