Shiozaki H, Ogawa Y, Ogawa M, Fujimoto J, Kido Y, Miyamoto T, Tane H, Kokunai I, Ueno K, Kobayashi K
Gan To Kagaku Ryoho. 1984 Oct;11(10):2245-51.
Between January 1970 and December 1983, 148 patients of esophageal carcinoma were treated surgically in the 2nd Department of Surgery, Osaka University Medical School. Among these patients, 70 (48.6%) with suspected invasion to neighboring structures were treated with preoperative chemotherapy, radiotherapy or a combination of both. The chemotherapeutic agents used were tegafur (FT-207)-suppository, bleomycin (BLM) or peplomycin (PEP). Radiotherapy (3000-4000 cGy) for selected cases was begun at the same time as the chemotherapy. Three to four weeks after the chemotherapy and radiotherapy were completed, esophagectomy was performed. The effects of the preoperative adjuvant therapies were investigated in these patients, and the following results were obtained: A marked histological effect, according to the Guide Lines in Clinical and Pathologic Studies for Carcinoma of the Esophagus (Japanese Society for Esophageal Diseases, 1976) was found in 47.4% of the radiotherapy plus FT-207 group, 39.1% of the group receiving radiotherapy alone and 28.6% of the group receiving radiotherapy plus PEP or BLM. Radiotherapy plus FT-207 showed excellent effects (77.8% of this group showed marked histological effects) on well differentiated squamous cell carcinoma, as shown histologically by biopsy specimens. Tumors exhibiting sharp edged margins radiographically and endoscopically, showed a very good histological effect after preoperative radiotherapy. Metastatic lymph nodes present in the irradiation field, whose primary lesion showed a marked histological effect, also gave excellent results. Postoperative radiotherapy is also expected to be equally effective on these cases.
1970年1月至1983年12月期间，大阪大学医学院第二外科对148例食管癌患者进行了手术治疗。在这些患者中，70例（48.6%）怀疑侵犯邻近结构，接受了术前化疗、放疗或两者联合治疗。使用的化疗药物为替加氟（FT - 207）栓剂、博来霉素（BLM）或培普利欧霉素（PEP）。对部分病例在化疗同时开始放疗（3000 - 4000 cGy）。化疗和放疗完成3至4周后，进行食管切除术。对这些患者术前辅助治疗的效果进行了研究，结果如下：根据《食管癌临床与病理研究指南》（日本食管疾病学会，1976年），放疗联合FT - 207组有47.4%出现显著组织学效果，单纯放疗组为39.1%，放疗联合PEP或BLM组为28.6%。活检标本的组织学检查显示，放疗联合FT - 207对高分化鳞状细胞癌显示出极佳效果（该组77.8%出现显著组织学效果）。影像学和内镜检查显示边缘清晰的肿瘤，术前放疗后组织学效果非常好。照射野内存在的转移淋巴结，其原发灶显示出显著组织学效果的，术后效果也极佳。预计术后放疗对这些病例同样有效。
