Nissenbaum M, Browde S, Bezwoda W R, de Moor N G, Derman D P
Med Pediatr Oncol. 1984;12(3):204-8. doi: 10.1002/mpo.2950120312.
Fifty-eight patients with advanced head and neck cancer were entered into a randomised trial comparing chemotherapy (DDP + bleomycin) alone, multiple daily fractionated radiation therapy, and multimodality therapy consisting of chemotherapy plus multiple fractionated radiation therapy. Multimodal therapy gave a significantly higher response rate (69%) than either single-treatment modality. The use of a multiple daily dose fractionation allowed radiation therapy to be completed over 10 treatment days, and the addition of chemotherapy to the radiation treatment did not significantly increase toxicity. Patients receiving multimodal therapy also survived significantly longer (median 50 weeks) than those receiving single-modality therapy (median 24 weeks).
58例晚期头颈癌患者进入一项随机试验，比较单纯化疗（顺铂+博来霉素）、每日多次分割放射治疗以及化疗加多次分割放射治疗的多模式治疗。多模式治疗的缓解率（69%）显著高于任何一种单一治疗模式。采用每日多次剂量分割可使放射治疗在10个治疗日内完成，放射治疗中加入化疗并未显著增加毒性。接受多模式治疗的患者生存期（中位数50周）也显著长于接受单一模式治疗的患者（中位数24周）。
