Kubota K, Kubota R, Matsuzawa T
Oncology. 1984;41(3):217-21. doi: 10.1159/000225826.
To study why the tumor growth rate was different among host mice of different sexes and ages, we examined the role of sex hormones in the growth and development of mouse teratocarcinoma OTT6050 in vivo. Estrogen and progesterone showed enhancement of tumor growth, while ovariectomy resulted in partial growth inhibition. Testosterone, orchiectomy, and antiestrogen had no effects. We concluded that the differences in tumor growth rate in females of different ages were due to changes in serum estrogen and progesterone levels and that the constancy of the growth in adult males was due to absent effects of testosterone.
为研究不同性别和年龄的宿主小鼠肿瘤生长速率为何不同，我们在体内检测了性激素在小鼠畸胎瘤OTT6050生长发育中的作用。雌激素和孕酮可促进肿瘤生长，而卵巢切除则导致部分生长抑制。睾酮、睾丸切除及抗雌激素无此作用。我们得出结论，不同年龄雌性小鼠肿瘤生长速率的差异是由于血清雌激素和孕酮水平的变化，而成年雄性小鼠肿瘤生长的恒定是由于睾酮无作用。
