Kubota K, Kubota R, Matsuzawa T
Oncodev Biol Med. 1983;4(5):309-17.
The effects of estrogen, antiestrogen and ovariectomy on the growth of a mouse teratocarcinoma, OTT6050, were studied in vivo. Subcutaneous tumors transplanted in syngeneic 129/Sv male and female mice were measured, and tumor-growth curves were constructed using the products of three principal tumor diameters, designated tumor volume. There was a linear correlation between the measured tumor volume and the actual excised tumor volume. The tumor growth rate in estrogen-treated groups was significantly greater than that in the control group, and the difference in tumor volume between treated groups and controls increased with time. However, dose responsiveness was not observed. In antiestrogen-treated or ovariectomized mice, tumor growth was partially inhibited only at the early stages. The mean survival time of estrogen-treated and ovariectomized groups was shorter than that of controls, while that of the antiestrogen-treated group was identical to that of controls. Histologically, no specifically different types of differentiated tissues were observed in any group. Our experiments show that estrogen is one important factor which stimulates the growth of one form of teratocarcinoma.
在体内研究了雌激素、抗雌激素和卵巢切除对小鼠畸胎癌OTT6050生长的影响。测量了移植到同基因129/Sv雄性和雌性小鼠皮下的肿瘤，并使用三个主要肿瘤直径的乘积构建肿瘤生长曲线，即肿瘤体积。测量的肿瘤体积与实际切除的肿瘤体积之间存在线性相关性。雌激素处理组的肿瘤生长速率显著高于对照组，处理组与对照组之间的肿瘤体积差异随时间增加。然而，未观察到剂量反应性。在抗雌激素处理或卵巢切除的小鼠中，仅在早期阶段肿瘤生长受到部分抑制。雌激素处理组和卵巢切除组的平均生存时间短于对照组，而抗雌激素处理组的平均生存时间与对照组相同。组织学上，任何组均未观察到特异性不同类型的分化组织。我们的实验表明，雌激素是刺激一种形式的畸胎癌生长的一个重要因素。
