Bienvenu J
Ann Biol Clin (Paris). 1984;42(1):47-52.
An inflammatory reaction protein is a protein whose rate of synthesis is greater than its rate of catabolism in the presence of an inflammatory process. This is reflected by an increase in its plasma concentration. In man, orosomucoid, alpha-1 antitrypsin, alpha-1 anti-chymotrypsin, haptoglobin, ceruloplasmin, fibrinogen and C reactive protein (CRP), all conform to this definition. The authors present the principal physicochemical properties of the proteins. However, none of these proteins, on its own, constitutes an ideal marker of inflammation. The authors also propose the use of an inflammatory miniprofile consisting of "CRP, orosomucoid and haptoglobin" to detect, quantify and follow an inflammatory reaction. The authors stress the importance of using a rapid assay technique like immunonephelemetry , which is essential for the clinical usefulness of these proteins. Finally, they discuss the process of synthesis and the biological role of these proteins.
炎症反应蛋白是一种在炎症过程中其合成速率大于分解代谢速率的蛋白质。这表现为其血浆浓度升高。在人类中，类黏蛋白、α1抗胰蛋白酶、α1抗糜蛋白酶、触珠蛋白、铜蓝蛋白、纤维蛋白原和C反应蛋白（CRP）均符合这一定义。作者介绍了这些蛋白质的主要物理化学性质。然而，这些蛋白质单独一种都不构成理想的炎症标志物。作者还提议使用由“CRP、类黏蛋白和触珠蛋白”组成的炎症微谱来检测、量化和跟踪炎症反应。作者强调使用免疫比浊法等快速检测技术的重要性，这对于这些蛋白质的临床应用至关重要。最后，他们讨论了这些蛋白质的合成过程和生物学作用。
