甲胎蛋白基因表达的组织特异性调控

Tissue specific control of alpha-fetoprotein gene expression.

作者信息

Cote G J, Chiu J F

出版信息

Biochem Biophys Res Commun. 1984 Apr 30;120(2):677-85. doi: 10.1016/0006-291x(84)91309-3.

PMID:6203525

Abstract

The expression of the alpha-fetoprotein (AFP) gene was studied in rat liver and kidney. A significant level of AFP mRNA was found in neonatal liver and kidney, but not in adult tissues. Unlike liver the re-expression of AFP mRNA was not seen upon chemically induced regeneration of the kidney. Treatment of neonatal rats with dexamethasone caused a decrease in liver AFP mRNA levels, but a similar decrease was not apparent in kidney. Northern analysis revealed AFP mRNA size to be identical in neonatal liver and kidney. The results suggest different gene regulatory mechanisms in liver and kidney for the AFP gene.

摘要

在大鼠肝脏和肾脏中研究了甲胎蛋白（AFP）基因的表达。在新生大鼠的肝脏和肾脏中发现了显著水平的AFP mRNA，但在成年组织中未发现。与肝脏不同，在化学诱导的肾脏再生过程中未观察到AFP mRNA的重新表达。用地塞米松处理新生大鼠导致肝脏AFP mRNA水平降低，但在肾脏中未出现类似的降低。Northern分析显示，新生大鼠肝脏和肾脏中的AFP mRNA大小相同。结果表明，肝脏和肾脏中AFP基因的基因调控机制不同。