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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Li P M, Zhong J L, Chen R Q, Zhang X K, Ho K L, Chiu J F, Huang D P

Shanghai Institute of Biochemistry, Chinese Academy of Sciences, China.

Int J Biochem. 1989;21(1):15-22. doi: 10.1016/0020-711x(89)90022-0.

A saponin isolated from the Chinese herb zhi-mu (Anemarrhena asphodeloides Bunge) modifies alpha-fetoprotein production when injected into newborn rats. 2. The serum level of AFP was determined quantitatively by immunorocket electrophoresis. 3. AFP serum levels were reduced to 60% of the control by zhi-mu saponin (ZMS). 4. The lower AFP level in drug treated rat serum is not due to a change in the pattern of serum AFP variants. 5. AFP mRNA levels in ZMS-treated rat livers, measured by RNA dot hybridization, decreased to about 50% of control levels after 4 days treatment. 6. Results from tritium labeled dexamethasone competition assays suggest that ZMS may act on AFP gene expression through glucocorticoid receptor mediated action.

Li P M, Zhong J L, Chen R Q, Zhang X K, Ho K L, Chiu J F, Huang D P

Shanghai Institute of Biochemistry, Chinese Academy of Sciences, China.

Int J Biochem. 1989;21(1):15-22. doi: 10.1016/0020-711x(89)90022-0.

A saponin isolated from the Chinese herb zhi-mu (Anemarrhena asphodeloides Bunge) modifies alpha-fetoprotein production when injected into newborn rats. 2. The serum level of AFP was determined quantitatively by immunorocket electrophoresis. 3. AFP serum levels were reduced to 60% of the control by zhi-mu saponin (ZMS). 4. The lower AFP level in drug treated rat serum is not due to a change in the pattern of serum AFP variants. 5. AFP mRNA levels in ZMS-treated rat livers, measured by RNA dot hybridization, decreased to about 50% of control levels after 4 days treatment. 6. Results from tritium labeled dexamethasone competition assays suggest that ZMS may act on AFP gene expression through glucocorticoid receptor mediated action.