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[单次给予乙醇对大鼠大脑皮质细胞核行为及RNA合成活性的影响]

[Effect of a single ethanol administration on the behavior and the RNA-synthesizing activity of the cell nuclei of the cerebral cortex of the rat].

作者信息

Beliavtseva L M, Kulikova O G, Shabanov P D, Razumovskaia N I

出版信息

Farmakol Toksikol. 1984 May-Jun;47(3):38-41.

PMID:6203776
Abstract

A single intraperitoneal injection of ethanol (2 g/kg) disturbed the learning and performance of one trial passive avoidance task and decreased (by 14 %) the level of RNA-synthesizing activity of brain cortical synaptosomes in rats. The data obtained are discussed in accordance with the hypothesis that ethanol affects synaptic transmission in the central nervous system.

摘要

腹腔注射一次乙醇(2克/千克)会干扰大鼠单次被动回避任务的学习和表现,并使大鼠大脑皮质突触体的RNA合成活性水平降低(14%)。根据乙醇影响中枢神经系统突触传递这一假设对所获数据进行了讨论。

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