Production of human interferons: an overview.

The world-wide increased demand for human interferons (IFNs), mainly for clinical trials, has led to the development of procedures for production of various types of IFNs. Today, human IFNs: leukocyte, fibroblast, lymphoblastoid, immune and genetically-engineered (recombinant) IFNs are produced in large quantities. Each IFN has its own production methodology based on the characteristics of the producer cells, IFN inducer and the IFN itself. Various equipment is being used for production of crude IFN, its concentration and purification. Various IFN preparations are being supplied in different specific activities. Final IFN preparations are tested according to strict regulations established by Health authorities.