El-Bassiouni E A, Mostafa M H, El-Sewedy S M, El-Meligy S, Abdel-Aziz T, Abdel-Rafee A
J Environ Sci Health B. 1984 Mar;19(2):193-207. doi: 10.1080/03601238409372425.
The time course of effects of S. mansoni infection on hepatic microsomal drug metabolizing enzymes was studied in swiss albino mice. Aminopyrine demethylase and aniline hydroxylase showed increases in activity, reaching a peak 30 days post infection. Both enzymes demonstrated a steady decline thereafter. On day 60, the level of aminopyrine demethylase was comparable to that of uninfected mice. On the other hand, the activity of aniline hydroxylase was lower than the control values. Treatment with lindane (40 mg/Kg/day X 3) increased the activity of both enzymes after different durations of disease induction. Changes in hepatic microsomal enzymes in S. mansoni infection may alter the intensity and duration of pharmacologic or toxic effects of drugs eliminated from the body through metabolic transformation.
在瑞士白化小鼠中研究了曼氏血吸虫感染对肝脏微粒体药物代谢酶影响的时间进程。氨基比林脱甲基酶和苯胺羟化酶活性增加，在感染后30天达到峰值。此后两种酶活性均稳步下降。在第60天，氨基比林脱甲基酶水平与未感染小鼠相当。另一方面，苯胺羟化酶活性低于对照值。用林丹（40mg/Kg/天×3）治疗在疾病诱导不同持续时间后增加了两种酶的活性。曼氏血吸虫感染时肝脏微粒体酶的变化可能会改变通过代谢转化从体内消除的药物的药理或毒性作用的强度和持续时间。
