Frenk E, Marazzi A
J Invest Dermatol. 1984 Jul;83(1):23-5. doi: 10.1111/1523-1747.ep12261648.
The numerical keratinocyte to melanocyte relation was studied in café au lait spots and adjacent normally pigmented skin of 9 patients with classical neurofibromatosis. Compared to normal skin of healthy individuals, the keratinocyte:melanocyte ratio distributions obtained in neurofibromatosis indicated a shift to lower values in the biopsies of café au lait spots and normally pigmented skin. These results are evidence in favor of an impaired tissue organization of the epidermis in neurofibromatosis with regard to the keratinocyte-melanocyte interrelation.
对9例典型神经纤维瘤病患者的咖啡斑及相邻正常色素沉着皮肤中的角质形成细胞与黑素细胞的数量关系进行了研究。与健康个体的正常皮肤相比，神经纤维瘤病患者中获得的角质形成细胞：黑素细胞比率分布表明，在咖啡斑和正常色素沉着皮肤的活检中该比率向较低值偏移。这些结果证明，就角质形成细胞-黑素细胞相互关系而言，神经纤维瘤病患者的表皮组织受损。
