12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯对C3H小鼠胚胎细胞克隆系中X射线转化的增强作用。
Enhancement of X-ray transformation by 12-O-tetradecanoyl-phorbol-13-acetate in a cloned line of C3H mouse embryo cells.
作者信息
Kennedy A R, Mondal S, Heidelberger C, Little J B
出版信息
Cancer Res. 1978 Feb;38(2):439-43.
A phorbol ester promoting agent, 12-O-tetradecanoyl-phorbol-13-acetate, enhances X-ray transformation in vitro in a two-stage fashion similar to that shown previously for ultraviolet radiation and chemical carcinogens. In studies with a mouse embryo-derived cell line (C3H/1OT 1/2 clone 8), there were clear interactive effects between X-radiation and 12-O-tetradecanoylphorbol-13-acetate. These were particularly marked when a minimally transforming X-ray dose (50 or 100 rads) was followed by 12-O-tetradecanoylphorbol-13-acetate treatment beginning either immediately after the radiation exposure or 48 to 96 hr later.
一种佛波酯促进剂，12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯，以类似于先前紫外线辐射和化学致癌物所显示的两阶段方式增强体外X射线转化作用。在用小鼠胚胎来源的细胞系（C3H/1OT 1/2克隆8）进行的研究中，X射线与12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯之间存在明显的相互作用。当在最小转化剂量的X射线（50或100拉德）照射后，立即或在照射后48至96小时开始用12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯处理时，这些相互作用尤为明显。
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