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12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯对C3H小鼠胚胎细胞克隆系中X射线转化的增强作用。

Enhancement of X-ray transformation by 12-O-tetradecanoyl-phorbol-13-acetate in a cloned line of C3H mouse embryo cells.

作者信息

Kennedy A R, Mondal S, Heidelberger C, Little J B

出版信息

Cancer Res. 1978 Feb;38(2):439-43.

PMID:620412
Abstract

A phorbol ester promoting agent, 12-O-tetradecanoyl-phorbol-13-acetate, enhances X-ray transformation in vitro in a two-stage fashion similar to that shown previously for ultraviolet radiation and chemical carcinogens. In studies with a mouse embryo-derived cell line (C3H/1OT 1/2 clone 8), there were clear interactive effects between X-radiation and 12-O-tetradecanoylphorbol-13-acetate. These were particularly marked when a minimally transforming X-ray dose (50 or 100 rads) was followed by 12-O-tetradecanoylphorbol-13-acetate treatment beginning either immediately after the radiation exposure or 48 to 96 hr later.

摘要

一种佛波酯促进剂，12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯，以类似于先前紫外线辐射和化学致癌物所显示的两阶段方式增强体外X射线转化作用。在用小鼠胚胎来源的细胞系（C3H/1OT 1/2克隆8）进行的研究中，X射线与12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯之间存在明显的相互作用。当在最小转化剂量的X射线（50或100拉德）照射后，立即或在照射后48至96小时开始用12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯处理时，这些相互作用尤为明显。

相似文献

1
Enhancement of X-ray transformation by 12-O-tetradecanoyl-phorbol-13-acetate in a cloned line of C3H mouse embryo cells.12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯对C3H小鼠胚胎细胞克隆系中X射线转化的增强作用。
Cancer Res. 1978 Feb;38(2):439-43.
2
Enhanced transformation of mouse 10T1/2 cells by 12-O-tetradecanoylphorbol-13-acetate following exposure to X-rays or to fission-spectrum neutrons.在暴露于X射线或裂变谱中子后，12-O-十四烷酰佛波醇-13-乙酸酯对小鼠10T1/2细胞的转化作用增强。
Cancer Res. 1982 Feb;42(2):477-83.
3
Effect of time and duration of exposure to 12-O-tetradecanoylphorbol-13-acetate on x-ray transformation of C3H 10T 1/2 cells.12-氧-十四烷酰佛波醇-13-乙酸酯作用时间和暴露时长对C3H 10T 1/2细胞X射线转化的影响
Cancer Res. 1980 Jun;40(6):1915-20.
4
DNA repair and malignant transformation: effect of X irradiation, 12-O-tetradecanoyl-phorbol-13-acetate, and protease inhibitors on transformation and sister-chromatid exchanges in mouse 10T 1/2 cells.DNA修复与恶性转化：X射线、12-O-十四烷酰佛波醇-13-乙酸酯及蛋白酶抑制剂对小鼠10T 1/2细胞转化和姐妹染色单体交换的影响
Radiat Res. 1979 Aug;79(2):241-55.
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Establishment of epithelial cell lines following exposure of cultured tracheal epithelium to 12-O-tetradecanoyl-phorbol-13-acetate.将培养的气管上皮暴露于12-O-十四烷酰佛波醇-13-乙酸酯后建立上皮细胞系。
Cancer Res. 1978 Oct;38(10):3563-5.
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Modification of sister chromatid exchanges and radiation-induced transformation in rodent cells by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and two retinoids.肿瘤促进剂12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯和两种类维生素A对啮齿动物细胞中姐妹染色单体交换及辐射诱导转化的影响
Cancer Res. 1981 Feb;41(2):655-9.
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Effects of promoters on DNA synthesis in C3H/10T1/2 mouse fibroblasts.启动子对C3H/10T1/2小鼠成纤维细胞DNA合成的影响。
Cancer Res. 1977 Sep;37(9):3223-7.
8
Two-stage chemical oncogenesis in cultures of C3H/10T1/2 cells.C3H/10T1/2细胞培养中的两阶段化学致癌作用。
Cancer Res. 1976 Jul;36(7 PT 1):2254-60.
9
Reduced trisialoganglioside synthesis in chemically but not mos-transformed mouse epidermal cells.在化学转化而非莫氏转化的小鼠表皮细胞中，三唾液酸神经节苷脂合成减少。
Cancer Res. 1984 Apr;44(4):1510-4.
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Ultraviolet light in the oncogenic transformation of cultured C3H/10T1/2 mouse embryo cells.紫外线在培养的C3H/10T1/2小鼠胚胎细胞致癌转化中的作用
Natl Cancer Inst Monogr. 1978 Dec(50):71-3.

引用本文的文献

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Selective down-regulation of protein kinase c-epsilon by carcinogens does not prevent stimulation of phospholipase D by phorbol ester and platelet-derived growth factor.致癌物对蛋白激酶c-ε的选择性下调并不妨碍佛波酯和血小板衍生生长因子对磷脂酶D的刺激。
Biochem J. 1994 Jun 15;300 ( Pt 3)(Pt 3):751-6. doi: 10.1042/bj3000751.
2
Tumor promoters increase the synthesis of a 32,000-dalton protein in BALB/c 3T3 cells.肿瘤启动子可增加BALB/c 3T3细胞中一种32000道尔顿蛋白质的合成。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1800-4. doi: 10.1073/pnas.79.6.1800.
3
On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.
关于复制子“错误启动”的代谢控制可能性：与哺乳动物细胞谱系中恶性表型出现的关系。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3673-7. doi: 10.1073/pnas.78.6.3673.
4
Enhancement of N-methyl-N'-nitro-N-nitrosoguanidine transformation of Syrian hamster cells by a phorbol diester is independent of sister chromatid exchanges and chromosome aberrations.佛波酯对叙利亚仓鼠细胞N-甲基-N'-硝基-N-亚硝基胍转化的增强作用与姐妹染色单体交换和染色体畸变无关。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7282-6. doi: 10.1073/pnas.77.12.7282.
5
Relationship between x-ray exposure and malignant transformation in C3H 10T1/2 cells.C3H 10T1/2细胞中X射线照射与恶性转化的关系。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7262-6. doi: 10.1073/pnas.77.12.7262.
6
Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts.活性氧在小鼠胚胎C3H/10T1/2/C18成纤维细胞中作为转化促进剂起作用。
Proc Natl Acad Sci U S A. 1984 Apr;81(7):2085-7. doi: 10.1073/pnas.81.7.2085.
7
Modulation of adenovirus transformation by thyroid hormone.甲状腺激素对腺病毒转化的调节作用。
Proc Natl Acad Sci U S A. 1983 Jan;80(1):196-200. doi: 10.1073/pnas.80.1.196.
8
Can prenatal X-irradiation in mice act as an initiator stimulus in a modified 2-stage Berenblum/Mottram experiment with postnatal promotion with phorbol ester TPA?在一项经过改良的两阶段贝伦布卢姆/莫特拉姆实验中，用佛波酯TPA进行产后促癌，小鼠产前X射线照射能否起到引发刺激作用？
J Cancer Res Clin Oncol. 1980;97(2):109-17. doi: 10.1007/BF00409896.
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The effect of tumor promoters and antagonists on in vitro directional migration of 10T1/2 mouse embryo cells.肿瘤启动子和拮抗剂对10T1/2小鼠胚胎细胞体外定向迁移的影响。
Cell Biol Toxicol. 1985 Jun;1(3):145-57. doi: 10.1007/BF00120161.
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Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion.佛波酯对小鼠和人类髓系白血病细胞正常分化的调节作用及肿瘤促进机制
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5158-62. doi: 10.1073/pnas.76.10.5158.