Richardson P M, Issa V M
Nature. 1984;309(5971):791-3. doi: 10.1038/309791a0.
The success of peripheral and fetal neural tissue in promoting outgrowth of axons from the adult mammalian central nervous system has tended to focus attention on local interactions between extending axons and their environment. The contribution to axon regeneration of biochemical and morphological changes in injured neurones is more difficult to evaluate. We report here that long spinal axons of primary sensory neurones are 100 times more likely to regenerate into peripheral nerve grafts if their peripheral axons are also cut. Regenerative behaviour at the axon tip seems to be strongly influenced by inducible events in the nerve cell.
外周和胎儿神经组织在促进成年哺乳动物中枢神经系统轴突生长方面的成功，往往使人们将注意力集中在延伸轴突与其周围环境之间的局部相互作用上。损伤神经元中生化和形态学变化对轴突再生的贡献则更难评估。我们在此报告，初级感觉神经元的长脊髓轴突，如果其外周轴突也被切断，那么它们长入外周神经移植物的可能性要高出100倍。轴突末端的再生行为似乎受到神经细胞中可诱导事件的强烈影响。
