Jancsàr S M, Leonard B E
Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(2):263-9. doi: 10.1016/0278-5846(84)90163-5.
Bilateral ablation of the olfactory bulbs caused marked changes in the 'turnover' of several neurotransmitters in the amygdaloid cortex and the mid-brain areas of the rat brain. Following tyrosine and tryptophan hydroxylase inhibition, the decrease in the concentration of noradrenaline and serotonin respectively in the amygdaloid cortex was not so marked in the bulbectomized rats as in their controls. This suggests that the 'turnover' of these biogenic amines is reduced following bulbectomy. Following GABA transaminase inhibition, the increase in the concentration of GABA in this region was increased compared to the controls thereby suggesting that the 'turnover' of the inhibitory neurotransmitter was enhanced, glutamate decarboxylase activity was also increased in the amygdaloid cortex. No changes were found in the 'turnover' of noradrenaline or serotonin in the mid-brain but that of dopamine was decreased as was the activity of glutamate decarboxylase. It is concluded that changes in neurotransmitter 'turnover' in these brain regions are attributable to the destruction of the olfactory bulbs and may contribute to the behavioural deficits which we, and others, have reported elsewhere.
双侧切除嗅球会使大鼠大脑杏仁核皮质和中脑区域中几种神经递质的“更新率”发生显著变化。在抑制酪氨酸和色氨酸羟化酶后，与对照组相比，嗅球切除大鼠杏仁核皮质中去甲肾上腺素和血清素浓度的降低并不那么明显。这表明嗅球切除后这些生物胺的“更新率”降低。在抑制GABA转氨酶后，与对照组相比，该区域GABA的浓度增加，从而表明抑制性神经递质的“更新率”增强，杏仁核皮质中的谷氨酸脱羧酶活性也增加。中脑中去甲肾上腺素或血清素的“更新率”没有变化，但多巴胺的“更新率”降低，谷氨酸脱羧酶的活性也降低。得出的结论是，这些脑区神经递质“更新率”的变化归因于嗅球的破坏，并且可能导致我们和其他人在其他地方报道过的行为缺陷。
