Swierstra B A, van Oosterhout F J, Ausema B, Bakker W H, van der Pompe W B, Schouten H J
Acta Orthop Scand. 1984 Jun;55(3):251-3. doi: 10.3109/17453678408992349.
A hundred and fifty-two patients who were to undergo major orthopaedic surgery were divided into two groups in order to study the value of dextrans administered as adjuvants to oral anticoagulants in the prevention of deep venous thrombosis. The control group had oral anticoagulants only from the evening before the day of operation, aimed at the 15 per cent thrombotest level. The dextran group had peroperative and postoperative dextran infusions as well. Radionuclide venography was used for thrombosis detection. The dextran group had a lower incidence of thrombosis, but more haemorrhagic problems. The incidence of thrombosis was high in both groups.
152名即将接受大型骨科手术的患者被分为两组，以研究右旋糖酐作为口服抗凝剂的辅助药物在预防深静脉血栓形成中的价值。对照组仅在手术前一天晚上开始使用口服抗凝剂，目标是使凝血酶试验水平达到15%。右旋糖酐组在手术期间和术后还输注了右旋糖酐。采用放射性核素静脉造影术检测血栓形成情况。右旋糖酐组的血栓形成发生率较低，但出血问题较多。两组的血栓形成发生率都很高。
