雌激素的血清竞争物——大鼠α1-甲胎蛋白的相互作用。鉴定为非酯化脂肪酸混合物。
The serum competitor of oestrogen--rat alpha 1-foetoprotein interactions. Identification as a mixture of non-esterified fatty acids.
作者信息
Vallette G, Benassayag C, Savu L, Delorme J, Nunez E A, Doumas J, Maume G, Maume B F
出版信息
Biochem J. 1980 Jun 1;187(3):851-6. doi: 10.1042/bj1870851.
Abstract
The novel endogenous serum ligands of rat alpha 1-foetoprotein previously demonstrated in different mammalian sera were identified by g.l.c.--mass-spectrometric methods as a mixture of non-esterified long-chain and predominantly unsaturated fatty acids. Detailed comparative analyses of these ligands extracted from foetal- and pregnant-rat sera, rat amniotic fluid and foetal human sera are presented. We also show that an important fraction of these ligands remains associated with the rat alpha 1-foetoprotein after purification; analyses are given for the composition of this lipid moiety of the foetoprotein. The physiological relevance of these results is discussed.
摘要
先前在不同哺乳动物血清中证实的大鼠α1-甲胎蛋白的新型内源性血清配体，通过气相色谱-质谱法鉴定为非酯化长链且主要为不饱和脂肪酸的混合物。本文对从胎鼠和孕鼠血清、大鼠羊水及人胎血清中提取的这些配体进行了详细的比较分析。我们还表明，这些配体的一大部分在纯化后仍与大鼠α1-甲胎蛋白结合；文中给出了该甲胎蛋白脂质部分的组成分析。讨论了这些结果的生理相关性。
相似文献
1
The serum competitor of oestrogen--rat alpha 1-foetoprotein interactions. Identification as a mixture of non-esterified fatty acids.雌激素的血清竞争物——大鼠α1-甲胎蛋白的相互作用。鉴定为非酯化脂肪酸混合物。
Biochem J. 1980 Jun 1;187(3):851-6. doi: 10.1042/bj1870851.
2
[Free polyunsaturated fatty acids, estrogens and fetoproteins].[游离多不饱和脂肪酸、雌激素和甲胎蛋白]
Ann Nutr Aliment. 1980;34(2):219-28.
3
Relations between fatty acids and oestrogen binding properties of pure rat alpha 1-foetoprotein.大鼠纯α1-甲胎蛋白的脂肪酸与雌激素结合特性之间的关系
Biochim Biophys Acta. 1979 Oct 4;587(2):227-37. doi: 10.1016/0304-4165(79)90356-8.
4
High affinity of nonesterified polyunsaturated fatty acids for rat alpha-fetoprotein (AFP).非酯化多不饱和脂肪酸对大鼠甲胎蛋白（AFP）具有高亲和力。
Oncodev Biol Med. 1980 Aug;1(1):27-36.
5
Rat alpha-foetoprotein. Purification, physicochemical characterization, oestrogen-binding properties and chemical modification of the thiol group.大鼠甲胎蛋白。纯化、理化特性、雌激素结合特性及巯基的化学修饰。
Biochem J. 1978 Oct 1;175(1):73-81. doi: 10.1042/bj1750073.
6
High affinity of alpha-foetoprotein for arachidonate and other fatty acids.甲胎蛋白对花生四烯酸及其他脂肪酸的高亲和力。
Biochem J. 1980 Aug 15;190(2):301-5. doi: 10.1042/bj1900301.
7
Unsaturated fatty acids as endogenous inhibitors of tamoxifen binding to anti-oestrogen-binding sites.不饱和脂肪酸作为他莫昔芬与抗雌激素结合位点结合的内源性抑制剂。
Biochem J. 1986 Aug 1;237(3):749-55. doi: 10.1042/bj2370749.
8
9
Rat and human embryo and post-natal sera contain a potent endogenous competitor of estrogen-rat alpha-fetoprotein interactions.大鼠和人类胚胎及出生后血清中含有一种有效的雌激素与大鼠甲胎蛋白相互作用的内源性竞争物。
Steroids. 1977 Dec;30(6):771-85. doi: 10.1016/s0039-128x(77)80023-8.
10
Drug-binding properties of rat alpha-foetoprotein. Specificities of the phenylbutazone-binding and warfarin-binding sites.大鼠甲胎蛋白的药物结合特性。保泰松结合位点和华法林结合位点的特异性。
Biochem J. 1986 Oct 15;239(2):451-8. doi: 10.1042/bj2390451.
引用本文的文献
1
Homology modeling, molecular docking, and molecular dynamics simulations elucidated α-fetoprotein binding modes.同源建模、分子对接和分子动力学模拟阐明了甲胎蛋白的结合模式。
BMC Bioinformatics. 2013;14 Suppl 14(Suppl 14):S6. doi: 10.1186/1471-2105-14-S14-S6. Epub 2013 Oct 9.
2
Role for estradiol in female-typical brain and behavioral sexual differentiation.雌二醇在雌性典型脑和行为性分化中的作用。
Front Neuroendocrinol. 2008 Jan;29(1):1-16. doi: 10.1016/j.yfrne.2007.06.001. Epub 2007 Jul 26.
3
Secretion and glycosylation of alpha-foetoprotein by the mouse yolk sac.小鼠卵黄囊α-甲胎蛋白的分泌与糖基化
Biochem J. 1983 May 15;212(2):313-20. doi: 10.1042/bj2120313.
4
Unsaturated fatty acids as endogenous inhibitors of tamoxifen binding to anti-oestrogen-binding sites.不饱和脂肪酸作为他莫昔芬与抗雌激素结合位点结合的内源性抑制剂。
Biochem J. 1986 Aug 1;237(3):749-55. doi: 10.1042/bj2370749.
5
Drug-binding properties of human alpha-foetoprotein.人甲胎蛋白的药物结合特性
Biochem J. 1985 Oct 1;231(1):189-91. doi: 10.1042/bj2310189.
本文引用的文献
1
INFLUENCE OF DIET ON BLOOD SERUM LIPIDS IN PREGNANT WOMEN AND NEWBORN INFANTS.饮食对孕妇及新生儿血清脂质的影响
Am J Clin Nutr. 1964 Jul;15:11-9. doi: 10.1093/ajcn/15.1.11.
2
Effects of diet on serum lipids of fetal, neonatal, and pregnant rabbits.饮食对胎儿、新生儿及怀孕兔子血脂的影响。
Am J Physiol. 1961 Oct;201:611-6. doi: 10.1152/ajplegacy.1961.201.4.611.
3
[Not Available].[无可用内容]。
FEBS Lett. 1972 Apr 15;22(1):113-116. doi: 10.1016/0014-5793(72)80233-3.
4
Effects of dietary fat on mammary carcinogenesis by 7,12-dimethylbenz(alpha)anthracene in rats.膳食脂肪对大鼠经7,12-二甲基苯并(a)蒽诱导的乳腺癌发生的影响。
Cancer Res. 1967 Oct;27(10):1737-42.
5
[Identification and preliminary purification of the feto-protein binding the estrogens in the serum of newborn rats].[新生大鼠血清中结合雌激素的甲胎蛋白的鉴定与初步纯化]
C R Acad Hebd Seances Acad Sci D. 1971 Aug 30;273(9):831-4.
6
Comparative study on the binding of estrogens by human and rat serum proteins in development.发育过程中人类和大鼠血清蛋白与雌激素结合的比较研究。
Biochem Biophys Res Commun. 1974 Mar 15;57(1):126-33. doi: 10.1016/s0006-291x(74)80366-9.
7
Estrogen-binding properties of rat, mouse and man fetospecific serum proteins. Demonstration by immuno-autoradiographic methods.大鼠、小鼠和人类胎儿特异性血清蛋白的雌激素结合特性。通过免疫放射自显影法证明。
Biochem Biophys Res Commun. 1972 Feb 16;46(3):1175-80. doi: 10.1016/s0006-291x(72)80098-6.
8
Binding of estrogens to serum protein of rats treated with hepatocarcinogenic compounds.
Biomedicine. 1973 Nov;18(6):514-20.
9
Fetal accumulation of long-chain polyunsaturated fatty acids.
Adv Exp Med Biol. 1977;83:135-43. doi: 10.1007/978-1-4684-3276-3_13.
10
Do fatty acids exert a specific effect on human lymphocyte transformation in vitro?
Int Arch Allergy Appl Immunol. 1978;57(2):171-6. doi: 10.1159/000232099.
Zotero 插件